Utility and limitations of the use of donor-derived cell-free DNA in kidney transplantation

Table 8 Summary of diagnostic metrics to detect subclinical acute rejection

Diagnostic performance	GEP alone	dd-cfDNA alone	Positive = GEP + dd-cfDNA
Sensitivity	0.43	0.47	0.20
Specificity	0.85	0.88	0.98
Positive predictive value	0.47	0.56	0.81
Negative predictive value	0.82	0.84	0.80
Accuracy	0.75	0.78	0.80

GEP: Gene expression profile; dd-cfDNA: Donor-derived cell-free DNA.