King's College criteria and the Clichy-Villejuif criteria require adjustments for assessing acute liver failure due to yellow fever

Table 1 Liver transplant indication criteria: King's College and Clinic-Villejuif

King's College criteria		Clichy-Villejuif criteria
Paracetamol induced liver failure (Acetaminophen)	Non-paracetamol induced liver failure
Arterial potential of hydrogen < 7.3 (irrespective of the grade of encephalopathy)	PT > 100 seconds (INR > 6.5)	Age: Patients over the age of 30 years are at higher risk and are more likely to need a transplant
All three of the following	Any three of the following	Factor V levels
PT > 100 seconds (INR > 6.5)	Age < 10 years or > 40 years	Factor V level < 20% of normal for patients over 30 years old
Serum creatinine > 3.4 mg/dL (300 μmol/L)	Etiology: Non-A hepatitis, non-B hepatitis, and idiosyncratic drug reactions	Factor V level < 30% of normal for patients under 30 years old
Grade III or IV encephalopathy	Duration of jaundice before encephalopathy > 7 days. Prothrombin time > 50 seconds (INR > 3.5). Serum bilirubin > 17.5 mg/dL (300 μmol/L)
		Grade of encephalopathy
		Presence of grade III or IV encephalopathy indicates a severe case

INR: International normalized ratio; PT: Prothrombin time.