Genitourinary tumors and liver transplantation: A comprehensive review

Table 2 Possible proposal of waiting time until liver transplantation for recipients with a history of genitourinary malignancy (adapted from[29])

Cancer	Tumor stage and/or grade	Time interval to transplant
Prostate	Up to T3 stage and regardless of Gleason score	No wait time
	Metastatic castration-sensitive prostatic cancer	Stable disease for 2 yr with prolonged estimated life expectancy – 2 yr
	Metastatic castration-resistant	Not a LT candidate
Renal cell carcinoma	T1a (≤ 4 cm) and T1b (4-7 cm) with N0, M0 and Fuhrman grade I/II	No wait time
	T1b, N0, M0 and FG III/IV and T2N0M0	2 yr
	T3 and T4 – both N0M0	Minimum 2 yr then reassess
	Any T, N+, M+	Not a LT candidate
Bladder	NMIBC (solitary tumor, low grade, absence of carcinoma in situ (CIS), high grade tumor < 3 cm)	6 mo
	NMIBC (any CIS, high-grade tumor > 3 cm, high grade T1 tumor, any recurrent high-grade Ta tumor, lymphovascular invasion)	2 yr
	MIBC, postradical cystectomy	2 yr
	MIBC, post chemoradiation	Not a LT candidate

FG: Fuhrman grade; LT: Liver transplantation; NMIBC: Nonmuscle-invasive bladder cancer; MIBC: Muscle-invasive bladder cancer.