Mortality assessment for pancreas transplants in the United States over the decade 2008-2018

Table 2 Adjusted Cox proportional hazards models comparing transplanted to non-transplanted patients within each transplant group

	SPK		PAK		PTA
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Transplanted (No)	Reference	Reference	Reference	Reference	Reference	Reference
Transplanted (Yes)	0.21 (0.19, 0.25)	< 0.001	1.68 (0.99, 2.87)	0.06	1.01 (0.53, 1.95)	0.97
Age at registration	1.01 (1.00, 1.02)	0.04	1.03 (1.00, 1.06)	0.02	1.03 (1.00, 1.06)	0.03
Gender (F)	Reference	Reference	Reference	Reference	Reference	Reference
Gender (M)	0.97 (0.86, 1.08)	0.55	0.55 (0.35, 0.88)	0.01	1.46 (0.90, 2.37)	0.13
Race (White)	Reference	Reference	Reference	Reference	Reference	Reference
Race (Black)	1.05 (0.91, 1.22)	0.47	1.82 (0.89, 3.71)	0.1	0.34 (0.05, 2.54)	0.29
Race (Other)	0.74 (0.62, 0.89)	0.001	0.77 (0.34, 1.74)	0.53	1.27 (0.45, 3.61)	0.66
BMI (Normal)	Reference	Reference	Reference	Reference	Reference	Reference
BMI (Obese)	0.76 (0.63, 0.90)	0	0.46 (0.21, 1.04)	0.06	0.80 (0.39, 1.65)	0.54
BMI (Overweight)	0.87 (0.77, 0.99)	0.03	0.66 (0.40, 1.10)	0.11	0.85 (0.50, 1.46)	0.57
BMI (Underweight)	1.16 (0.77, 1.75)	0.48	3.15 (0.90, 10.96)	0.07	1.76 (0.41, 7.64)	0.45
Duration of diabetes (yr)	1.00 (0.99, 1.01)	0.96	0.99 (0.96, 1.02)	0.62	0.98 (0.96, 1.01)	0.21
Karnofsky score (High)	Reference	Reference	Reference	Reference	Reference	Reference
Karnofsky score (Low)	0.98 (0.60, 1.60)	0.94	2.77 (0.96, 7.95)	0.06	3.07 (0.39, 24.14)	0.29
Karnofsky score (Middle)	1.42 (1.26, 1.60)	< 0.001	0.89 (0.52, 1.52)	0.66	2.22 (1.35, 3.64)	0
Peripheral vascular disease (No)	Reference	Reference	Reference	Reference	Reference	Reference
Peripheral vascular disease (Yes)	1.40 (1.19, 1.66)	< 0.001	0.98 (0.44, 2.16)	0.95	0.99 (0.47, 2.12)	0.99

SPK: Simultaneous pancreas-kidney; PAK: Pancreas after kidney; HR: Hazard ratios; CI: Confidence intervals; PTA: Pancreas transplant alone. Hazard ratios and 95% confidence intervals result from multivariate Cox proportional hazards models using transplant as a time-dependent covariate.