Long-term outcomes of pediatric liver transplantation in acute liver failure vs end-stage chronic liver disease: A retrospective observational study

Table 1 Donors and recipients demographics

Demographics	ALF (n = 37), %	ESCLD (n = 195), %	P value
Donor demographics
Sex
Male	45.7	46.9	0.902
Female	54.3	53.1
Weight, kg	66.2 (8–90)	65.8 (10–98)	0.912
Age, yr	35.2 (0.9–65)	29 (1–66)	0.039
Type of liver graft
Whole liver	14 (37.8)	38 (19.7)	0.016
Variant graft including split, reduced, living donor	23 (62.2)	155 (80.3)
Recipient demographics
Sex
Male	16 (43.2)	102 (52.3)	0.312
Female	21 (56.8)	93 (47.7)
Age at transplant, yr	8 (0.1–16.7)	5.4 (0.3–17.2)	0.031
Weight, kg	31 (2.7–66.5)	21 (4.7–89)	0.011
Etiology of liver disease
Alagille's syndrome	0 (0)	12 (6.2)	0.222
Alpha-1-AT deficiency	0 (0)	15 (7.7)	0.138
Autoimmune	4 (10.8)	13 (6.7)	0.487
Biliary atresia	0 (0)	92 (47.2)	< 0.001
Biliary cirrhosis	0 (0)	2 (1.0)	1.000
CF liver disease	0 (0)	13 (6.7)	0.232
Drug induced	2 (5.4)	0 (0)	0.025
Hepatitis A	2 (5.4)	0 (0)	0.025
HSV	2 (5.4)	0 (0)	0.025
Seronegative hepatitis	17 (45.9)	0 (0)	< 0.001
PFIC	0 (0)	29 (14.9)	0.006
Post-liver resection	2 (5.4)	0 (0)	0.025
PSC	0 (0)	8 (4.1)	0.361
Others	8 (21.6)	11 (5.6)	0.004
Location of the recipient when the graft is available
Home	0 (0)	137 (71.4)	< 0.001
Hospital	15 (40.5)	47 (24.5)	0.044
PICU not ventilated	7 (18.9)	5 (2.6)	0.001
PICU ventilated	15 (40.5)	3 (1.6)	< 0.001

ALF: Acute liver failure; CF: Cystic fibrosis; ESCLD: End-stage chronic liver disease; HSV: Herpes simplex virus; PFIC: Progressive familial intrahepatic cholestasis; PICU: Pediatric intensive care unit; PSC: Primary sclerosing cholangitis.