Analysis of the effects of donor and recipient hepatitis C infection on kidney transplant outcomes in the United States

Table 1 Characteristics of donors in the pre-direct-acting antivirals era and the post-direct-acting antivirals era

Characteristics		D-R-	D-R+	D+R-	D+R+	P value
n	Pre	116108	4646	550	2455
	Post	46099	1443	1082	1303
Age (median [IQR])	Pre	40.0 [23.0, 51.0]	40.0 [24.0, 51.0]	41.0 [34.0, 46.0]	42.0 [33.0, 49.0]	< 0.001
	Post	40.0 [27.0, 52.0]	42.0 [29.0, 52.0]	35.0 [29.0, 44.0]	32.0 [26.0, 39.0]	< 0.001
Gender = M (%)	Pre	69042 (59.5)	2762 (59.4)	380 (69.1)	1574 (64.1)	< 0.001
	Post	28136 (61.0)	853 (59.1)	617 (57.0)	818 (62.8)	0.012
BMI (median [IQR])	Pre	25.6 [22.4, 29.7]	25.6 [22.3, 29.4]	24.8 [22.1, 28.0]	25.1 [22.3, 28.6]	< 0.001
	Post	27.1 [23.4, 31.9]	27.5 [23.7, 32.2]	26.3 [23.3, 30.5]	25.6 [22.8, 29.4]	< 0.001
Race (%)
White	Pre	83490 (71.9)	3209 (69.1)	409 (74.4)	1824 (74.3)	< 0.001
African American		14085 (12.1)	698 (15.0)	91 (16.5)	341 (13.9)
Hispanic		14482 (12.5)	574 (12.4)	45 ( 8.2)	260 (10.6)
Other		4051 (3.5)	165 ( 3.6)	5 ( 0.9)	30 (1.2)
White	Post	31238 (67.8)	929 (64.4)	922 (85.2)	1103 (84.7)	< 0.001
African American		6325 (13.7)	273 (18.9)	44 (4.1)	58 (4.5)
Hispanic		6421 (13.9)	187 (13.0)	94 (8.7)	116 (8.9)
Other		2115 (4.6)	54 (3.7)	22 (2.0)	26 (2.0)
Cause of death (%)
Anoxia	Pre	19852 (17.1)	750 (16.1)	67 (12.2)	470 (19.1)	< 0.001
Cerebrovascular/stroke		44318 (38.2)	1800 (38.7)	196 (35.6)	985 (40.1)
Head trauma		48450 (41.7)	1926 (41.5)	281 (51.1)	960 (39.1)
Other		3488 (3.0)	170 (3.7)	6 (1.1)	40 (1.6)
Anoxia	Post	18056 (39.2)	574 (39.8)	779 (72.0)	882 (67.7)	< 0.001
Cerebrovascular/stroke		12337 (26.8)	397 (27.5)	109 (10.1)	127 (9.7)
Head trauma		14151 (30.7)	430 (29.8)	176 (16.3)	272 (20.9)
Other		1555 (3.4)	42 (2.9)	18 (1.7)	22 (1.7)
DCD = yes (%)	Pre	10101 (8.7)	368 (7.9)	11 (2.0)	105 (4.3)	< 0.001
	Post	10519 (22.8)	329 (22.8)	151 (14.0)	128 (9.8)	< 0.001
SCR (median [IQR])	Pre	1.0 [0.7, 1.3]	1.0 [0.7, 1.3]	0.9 [0.7, 1.2]	0.9 [0.7, 1.1]	< 0.001
	Post	0.9 [0.7, 1.4]	1.0 [0.7, 1.4]	0.9 [0.7, 1.3]	0.9 [0.7, 1.1]	< 0.001
History of diabetes = yes (%)	Pre	6712 (5.8)	254 (5.5)	14 (2.5)	95 (3.9)	< 0.001
	Post	3616 (7.8)	123 (8.5)	41 (3.8)	30 (2.3)	< 0.001
History of hypertension = yes (%)	Pre	28967 (24.9)	1137 (24.5)	114 (20.7)	576 (23.5)	0.038
	Post	13638 (29.6)	453 (31.4)	226 (20.9)	173 (13.3)	< 0.001
Smoking history = no (%)	Pre	78484 (67.6)	3039 (65.4)	234 (42.5)	1068 (43.5)	< 0.001
	Post	36564 (79.3)	1154 (80.0)	723 (66.8)	953 (73.1)	< 0.001

D(-/+) R(-/+), hepatitis C virus (-) or (+) donors into hepatitis C virus (-) or (+) recipients. BMI: Body mass index; DCD: Donation after circulatory death; IQR: Interquartile range; M: male; Pre: Pre-direct-acting antivirals era; Post: Post-direct-acting antivirals era; SCR: Serum creatinine.