Simultaneous nephrectomy during kidney transplantation for polycystic kidney disease does not detrimentally impact comorbidity and graft survival

Table 4 Overview of studies investigating the surgical comorbidity of a simultaneous native unilateral or bilateral nephrectomy during isolated kidney transplantation for autosomal dominant polycystic kidney disease

Ref.	Study group (n)	Type of donor	Isolated KT with simultaneous native bilateral or unilateral nephrectomy		KT alone	Study conclusions
			Bilateral	Unilateral
Nunes P et al[13], 2007	1 (143)	LD (6%) + DD (94%)		+		Comparable overall complication rate and graft survival after 5 years if unilateral nephrectomy is performed for creation of space for a renal allograft
	2 (16)	LD (2%) + DD (98%)			+
Kramer A et al[14], 2009	1 (20)	LD (100%)	+			Minimal morbidity of an associated bilateral nephrectomy during transplantation and graft and patient survival of 100% during 5-year follow-up
Skauby MH et al[15], 2012	1 (79); 2 (78)	LD (100%)	+		+	Associated bilateral nephrectomy results in a longer hospital stay and more postoperative complications. No difference in 1- and 5-year patient and graft survival
Neeff HP et al[16], 2013	1 (100)	LD (38%) + DD (62%)		+		Routine ipsilateral nephrectomy, independent of volume of polycystic kidney, during transplantation is a safe procedure without endangering patient or graft survival. The death of 3 patients in the first year post-transplant is a concern
Ahmad SB et al[17], 2016	1 (66)	LD (100%)	+			In symptomatic patients with ADPKD, the combined procedure is advantageous, especially in terms of patient satisfaction
	2 (52)				+
Current study	1 (77)	LD (7.8%) + DD (92.2%)		+		Comparable surgical comorbidity and 1- and 5-year patient and graft survival
	2 (77)	LD (27.3%) + DD (72.7%)			+

ADPKD: Autosomal dominant polycystic kidney disease; DD: Deceased donor; LD: Living donor; KT: Kidney transplantation.