Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation: A retrospective, single center study

doi:10.5500/wjt.v11.i4.114

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World Journal of Transplantation

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2220-3230

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Transplant. Apr 18, 2021; 11(4): 114-128
Published online Apr 18, 2021. doi: 10.5500/wjt.v11.i4.114

Table 3 Donor and hypothermic machine perfusion pump characteristics for recipients with and without delayed graft function

	All patients	DGF	No DGF	P value
	n = 294	n = 79	n = 215	P value
Donor characteristics
Donor kidney				0.35
Left, n (%)	136 (46%)	33 (42%)	103 (48%)
Right, n (%)	158 (54%)	46 (58%)	112 (52%)
Donor location				0.001^a
Local, n (%)	158 (54%)	27 (34%)	131 (61%)
Import, n (%)	136 (46%)	52(66%)	84 (39%)
Kidney donor profile index, %	53 (33-81)	61 (40-85)	49 (28-75)	0.006^a
Donor age, yr	44 (32-56)	49 (36-56)	42 (30-55)	0.04^a
Donor body mass index, kg/m²	27 (23-31)	28 (25-33)	26 (23-31)	0.009^a
Donation after cardiac death, n (%)	50 (17%)	23 (29%)	27 (13%)	0.001^a
Donor cause of death				0.6
Anoxia, n (%)	119 (40%)	31 (39%)	88 (41%)
Head trauma, n (%)	76 (26%)	18 (23%)	58 (27%)
Stroke, n (%)	99 (34%)	30 (38%)	69 (32%)
Donor cardiac arrest, n (%)	141 (48%)	40 (51%)	101 (47%)	0.58
Donor medical history
Hypertension, n (%)	104 (35%)	32 (41%)	72 (33%)	0.28
Diabetes, n (%)	34 (12%)	12 (15%)	22 (10%)	0.24
Coronary artery disease, n (%)	27 (9%)	16 (20%)	11 (5%)	0.001^a
Smoking, n (%)	70 (24%)	20 (25%)	50 (23%)	0.73
Heavy alcohol use, n (%)	65 (22%)	13 (16%)	52 (24%)	0.15
Admit creatinine, mg/dL	1.1 (0.9-1.4)	1.1 (0.9-1.5)	1.1 (0.9-1.30)	0.2
Terminal creatinine, mg/dL	1.0 (0.7-1.6)	1.3 (0.81-2.8)	0.9 (0.7-1.4)	0.001^a
Terminal creatinine ≥ 1.9 mg/dL	63 (21%)	31 (39%)	32 (15%)	0.001^a
Donor Biopsy: % glomerulosclerosis	3.9 (0-8.3)	4.6 (1.7-10)	3.4 (0-7.6)	0.14
HMP pump characteristics
Cold ischemia time	28.5 (21.5-34.5)	30.6 (25.8-36.4)	26.4 (21.2-33.8)	0.009^a
Cold ischemia time ≥ 26 h	172 (59%)	58 (73%)	114 (53%)	0.002^a
Cold storage time, h	10.6 (6.8-20.6)	18.4 (7.1-24.7)	9.6 (6.8-18.9)	0.002^a
Cold storage duration ≥ 16 h	120 (41%)	46 (58%)	74 (34%)	0.001^a
Total pump time, h	13.3 (8.4-19.2)	13.1 (8.2-18.9)	13.4 (8.4-19.7)	0.37
Final pump parameters
Flow, mL/min	141 (123-156)	127 (117-148)	142 (126-159)	0.001^a
Resistance, mmHg/mL/min	0.20 (0.15-0.25)	0.24 (0.16-0.29)	0.19 (0.15-0.24)	0.001^a
Systolic pressure, mmHg	34 (29-40)	35 (30-40)	33 (27-39)	0.009^a
Diastolic pressure, mmHg	24 (18-29)	26 (19-30)	23 (18-29)	0.09
Pump flow < 150 mL/min	190 (65%)	65 (82%)	125 (58%)	0.001^a
Pump resistance ≥ 0.23 mmHg/mL/min	115 (39%)	47 (59%)	68 (32%)	0.001^a

Values are presented as medians with 25^th and 75^th percentiles, or as numbers (n) and percentages (%).

^aP < 0.05 denotes significance.

DGF: Delayed graft function; HMP: Hypothermic machine perfusion.

Citation: Mendez NV, Raveh Y, Livingstone JJ, Ciancio G, Guerra G, Burke III GW, Shatz VB, Souki FG, Chen LJ, Morsi M, Figueiro JM, Ibrahim TM, DeFaria WL, Nicolau-Raducu R. Perioperative risk factors associated with delayed graft function following deceased donor kidney transplantation: A retrospective, single center study. World J Transplant 2021; 11(4): 114-128
URL: https://www.wjgnet.com/2220-3230/full/v11/i4/114.htm
DOI: https://dx.doi.org/10.5500/wjt.v11.i4.114