Analysis of risk factors of suicidal ideation in adolescent patients with depression and construction of prediction model

Table 1 Comparison of general information between the two groups, n (%)

Characteristic	SI group (n = 91)	Non-SI group (n = 59)	t/χ2 value	P value
Sex
Male	25 (27.47)	20 (33.90)	0.704	0.402
Women	66 (72.53)	39 (66.10)
Age	14.165 ± 0.793	14.220 ± 0.789	0.186	0.157
Trauma history
Yes	39 (42.86)	8 (13.56)	14.28	0.001
No	52 (57.14)	51 (86.44)
Only child
Yes	60 (65.93)	40 (67.80)	0.056	0.813
No	31 (34.07)	19 (32.20)
Single parent
Yes	19 (20.88)	11 (18.64)	0.112	0.738
No	72 (79.12)	48 (81.36)
First-episode
Yes	66 (72.53)	46 (77.97)	0.560	0.454
No	25 (27.47)	13 (22.03)
Are there triggers
Yes	42 (46.15)	23 (38.98)	13.328	0.039
No	49 (53.85)	36 (61.02)
Ethnic groups
Han nationality	82 (90.11)	53 (89.83)	0.003	0.956
Ethnic minorities	9 (9.89)	6 (10.17)
Educational level
High school and above	39 (42.86)	21 (35.59)	0.787	0.375
Junior high school and below	52 (57.14)	38 (64.41)
Religious belief
Yes	3 (3.30)	4 (6.78)	0.976	0.323
No	88 (96.70)	55 (93.22)
Residential area
City	61 (67.03)	36 (61.02)	0.567	0.451
Rural	30 (32.97)	23 (38.98)
Economic situation
Poor	15 (16.48)	8 (13.56)	0.284	0.868
Medium	55 (60.44)	36 (61.02)
Better	21 (23.08)	15 (25.42)
Father's education level
Junior high school and below	65 (71.43)	42 (71.19)	0.001	0.974
High school and above	26 (28.57)	17 (28.81)
Mother's educational level
Junior high school and below	63 (69.23)	43 (72.88)	0.230	0.631
High school and above	28 (30.77)	16 (27.12)

SI: Suicidal ideation.

Table 2 Comparison of biochemical indices between the two groups

Index	SI group	Non-SI group	t value	P value
SF (μg/L)	71.010 ± 13.278	58.422 ± 17.842	-4.945	0.015
Folic acid (mmol/L)	4.350 ± 0.139	4.436 ± 0.172	11.864	0.053
Vitamin D3 (mg/L)	12.773 ± 0.836	13.200 ± 0.846	4.366	0.054
hs-CRP (mg/L)	4.115 ± 1.497	3.423 ± 1.012	-3.115	0.020
UA (mmol/L)	335.989 ± 16.667	330.924 ± 16.875	-1.809	0.861
TG (mmol/L)	1.073 ± 0.103	1.061 ± 0.105	-0.656	0.794
TC (mmol/L)	3.737 ± 0.048	3.737 ± 0.047	-0.023	0.949
HDL-C (mmol/L)	1.039 ± 0.210	1.174 ± 0.282	3.351	0.009
LDL-C (mmol/L)	2.079 ± 0.055	2.076 ± 0.061	-0.313	0.411
TP (g/L)	76.312 ± 1.088	75.951 ± 1.230	-1.881	0.062
ALB (g/L)	47.230 ± 0.916	46.716 ± 1.088	-3.549	0.081
TBIL (μmol/L)	14.964 ± 0.218	14.820 ± 0.203	-4.045	0.121
AST (U/L)	42.325 ± 0.543	41.897 ± 0.501	-4.852	0.089
TSH (mmol/L)	150.080 ± 1.180	149.890 ± 1.109	0.986	0.326
T3 (pmol/L)	1.519 ± 0.292	1.514 ± 0.246	-0.124	0.902
T4 [M(Q)pmol/L]	86.850 ± 18.366	87.285 ± 19.229	0.139	0.889
FT3 (pmol/L)	4.317 ± 0.501	4.250 ± 0.437	1.913	0.050
FT4 (pmol/L)	11.339 ± 1.965	11.244 ± 2.040	-0.284	0.777

SI: Suicidal ideation; SF: Serum ferritin; hs-CRP: High-sensitivity C-reactive protein; UA: Uric acid; TG: Triglyceride; TC: Total cholesterol; HDL-C: high-density lipoprotein; LDL-C: Low-density lipoprotein; TP: Total protein; ALB: Albumin; TBIL: Total bilirubin; AST: Aspartate transaminase; TSH: Thyroid-stimulating hormone; T₃: Triiodothyronine; T₄: Thyroxine; FT₃: Free T₃; FT₄: Free T₄.

Table 3 Multivariate analysis of suicidal ideation in adolescents with depression

Independent variable	B	SE	Wald	P value	OR	95%CI
Trauma history	1.106	0.519	4.552	0.033	3.023	1.094–8.354
Triggers	1.311	0.461	8.107	0.004	3.711	1.505–9.153
SF (μg/L)	0.051	0.014	12.598	0.000	1.052	1.023–1.082
hs-CRP (mg/L)	0.453	0.172	6.927	0.008	1.573	1.123–2.205
HDL-C (mmol/L)	-2.104	0.852	6.095	0.014	0.122	0.023–0.648
FT3 (pmol/L)	-1.217	0.502	5.886	0.078	0.296	0.111–0.791
Constant	-2.293	1.609	2.031	0.154	0.101	-

OR: Odds ratio; SF: Serum ferritin; hs-CRP: High-sensitivity C-reactive protein; HDL-C: High-density lipoprotein; FT₃: Free triiodothyronine.

Table 4 Diagnostic value of receiver operating characteristic curve evaluation index

Independent variable	Cutoff	AUC	Sensitivity	Specificity	Youden index	P value	95%CI
Trauma history	-	0.647	0.429	0.864	0.293	0.002	0.558–0.734
Triggers	-	0.651	0.538	0.763	0.301	0.002	0.562–0.740
SF (μg/L)	49.76	0.695	0.989	0.322	0.311	0.000	0.607–0.783
hs-CRP (mg/L)	3.829	0.643	0.593	0.712	0.305	0.003	0.556–0.731
HDL-C (mmol/L)	0.683	0.656	0.967	0.068	0.035	0.001	0.250–0.439

AUC: Area under the receiver operating characteristic curve; SF: Serum ferritin; hs-CRP: High-sensitivity C-reactive protein; HDL-C: High-density lipoprotein.