Antidepressant foods: An evidence-based nutrient profiling system for depression

Table 1 Levels of evidence

Levels of evidence: Observational studies	Levels of evidence: Experimental studies
1. At least 2 prospective cohort studies with adequate sample size and/or meta-analysis with narrow confidence intervals	1. At least 2 RCTs with adequate sample sizes, preferably placebo-controlled, and/or meta-analysis with narrow confidence intervals
2. At least 1 prospective cohort study with adequate sample size and/or meta-analysis with wide confidence intervals	2. At least 1 RCT with adequate sample size and/or meta-analysis with wide confidence intervals
3. Cross-sectional or case control studies	3. Non-randomized, controlled prospective studies (open-label) or high-quality retrospective studies (i.e., case series)
4. Expert opinion/consensus	4. Expert opinion/consensus
5. Evidence is equivocal/unavailable	5. Evidence is equivocal/unavailable

RCT: Randomized controlled trial.