Comparative effectiveness of quetiapine and haloperidol in delirium: A single blind randomized controlled study

Table 1 Sociodemographic, clinical profile, delirum subtype, Delirium Rating Scale-Revised-98 and mini mental status examination ratings for both the study groups

Variables	Haloperidol n = 32 mean (SD)	Quetiapine n = 31 mean (SD)	χ2/t-test
Age (yr)	44.40 ± 16.76 (range 18-76)	48.51 ± 19.75 (range 18-85)	0.89 (P = 0.37)
Age ≥ 60 yr	7 (32%)	12 (38.7%)	2.11 (0.146)
Education (No. of years)	9.81 ± 4.46 (range 0-15)	9.38 ± 4.03 (range 0-17)	0.396 (P = 0.693)
Male	28 (87.5%)	21 (67.74%)	3.55 (P = 0.06)
Locality- Urban	21 (65.6%)	24 (77.4%)	1.073 (P = 0.300)
Type of onset - hospital emergent	23 (71.87%)	25 (80.64%)	0.668 (P = 0.414)
Duration of delirium prior to assessment (d)	2.38 ± 1.81	2.83 ± 2.32	0.85 (P = 0.398)
Total IQCODE	3.01 ± 0.053	3.13 ± 0.40	1.57 (0.12)
Delirium subtype as per amended DMSS
Hyperactive	28 (87.5%)	27 (87.09%)
Hypoactive			5.36 (P = 0.76)
Mixed	3 (9.37%)	2 (6.45%)
	1 (3.12%)	2 (6.45%)
Mean dose (mg/d)	0.67 ± 0.35 (range 0.25-1.25)	26.63 ± 15.61 (range 12.5-75)
Mean number of etiologies	7.06 ± 3.31	6.58 ± 3.92	0.52 (P = 0.60)
DRS-R-98 total score at baseline	31.21 ± 2.40	31.83 ± 4.10	0.73 (P = 0.46)
DRS-R-98 scores (severity items only)
Day 0	24.81 ± 2.19	25.48 ± 3.60	0.89 (P = 0.37)
Day 1	20.46 ± 3.93	19.54 ± 6.40	0.68 (P = 0.49)
Day 2	15.43 ± 6.19	13.54 ± 7.67	1.07 (P = 0.28)
Day 3	11.46 ± 6.58	9.51 ± 7.29	1.11 (P = 0.26)
Day 4	8.65 ± 6.73	7.83 ± 7.42	0.45 (P = 0.64)
Day 5	6.46 ± 6.06	6.48 ± 6.84	473 (P = 0.749)1
Day 6	5.43 ± 5.84	5.58 ± 5.84	466.5 (P = 0.679)1
DRS-R-98 < 10 on day 0	0	0	-
DRS-R-98 < 10 on day 1	0	3 (9.67%)	FE = 0.11
DRS-R-98 < 10 on day 2	5 (15.62%)	8 (25.80%)	0.99 (P = 0.31)
DRS-R-98 < 10 on day 3	14 (43.75%)	16 (51.61%)	0.39 (P = 0.53)
DRS-R-98 < 10 on day 4	21 (65.62%)	20 (64.51%)	0.009 (P = 0.92)
DRS-R-98 < 10 on day 5	23 (71.85%)	22 (70.96%)	0.006 (P = 0.93)
DRS-R-98 < 10 on day 6	22 (68.75%)	21 (67.74%)	0.007 (P = 0.93)
MMSE scores
Day 0	7.50 ± 3.83	6.83 ± 4.45	0.63 (P = 0.53)
Day 1	11.31 ± 5.91	11.80 ± 6.02	0.328 (P = 0.74)
Day 2	15.50 ± 5.16	16.00 ± 6.37	0.343 (P = 0.73)
Day 3	18.28 ± 0.73	18.38 ± 6.26	0.070 (P = 0.94)
Day 4	20.34 ± 5.72	20.67 ± 6.41	0.218 (P = 0.828)
Day 5	21.93 ± 5.01	21.58 ± 5.74	0.263 (P = 0.794)
Day 6	23.00 ± 4.75	22.54 ± 5.34	0.354 (P = 0.724)

¹Mann-Whitney U value. DRS-R98: Delirium Rating Scale-Revised-98; MMSE: Mini mental status examination; FE: Fisher Exact test.