Voxel-based magnetic resonance imaging investigation of poor and preserved clinical insight in people with schizophrenia

Table 3 Group differences in grey matter volumes after co-varying for education and National Adult Reading Test IQ (height threshold P < 0.005)

Groups	BA	Size	Side	MNI			T value	Cluster P FWE-corrected unless shown in italics	Voxel P FWE-corrected
				X	Y	Z
Insight+ > Insight- patients
Superior Temporal gyrus	22	37261	R	63	-3	5	4.70	0.002	0.044
				45	20	-33	4.56		0.066
				66	-8	4	4.45		0.088
Precentral gyrus	4			66	-5	22	4.44		0.092
Inferior frontal gyrus	47			54	19	0	4.39		0.103
Precentral gyrus	6			64	0	26	4.28		0.137
Postcentral gyrus	43			66	-8	16	4.15		0.192
Inferior frontal gyrus	47	65047	L	-42	16	-4	4.65	< 0.001	0.050
				-38	14	-8	4.65		0.052
				-36	18	-10	4.52		0.073
Middle frontal gyrus	9			-37	19	35	4.52		0.073
Superior temporal gyrus	22			-61	-2	7	4.28		0.139
Precentral gyrus	44			-59	9	9	4.17		0.184
Parahippocampual gyrus	21			-34	-3	-36	4.10		0.213
Cuneus	18	24291	L	-5	-83	5	4.32	0.014	0.125
Cerebellum	-		R	35	-90	-17	4.17		0.181
Cuneus	18		R	26	-93	-18	3.73		0.466
Cerebellum	-		R	4	-61	2	3.80		0.409
Cuneus	18		R	5	-98	10	3.35		0.787
Medial frontal gyrus	10	16854	L	0	60	3	3.98	0.050	0.285
Superior frontal gyrus	9			0	51	26	3.64		0.544
Insight- > Insight+ patients
Nil significant
Healthy controls > Insight- patients
Inferior frontal gyrus	47	9770	L	-51	19	-2	3.68	0.036	0.511
Superior temporal gyrus	38			-21	5	-24	3.35		0.786
Inferior frontal gyrus	47			-26	18	-7	3.34		0.796
Parahippocampal gyrus	34			-16	4	-23	3.29		0.827
Inferior occipital gyrus	18	4935	L	-38	-92	-2	3.92	0.122	0.323
Middle occipital gyrus	19			-52	-76	-10	3.70		0.494
				-44	-83	8	3.37		0.775
Middle temporal gyrus	18			-43	-81	13	3.22		0.873
Cerebellum (posterior lobe)	-	6085	R	35	-90	-17	3.68	0.089	0.304
				11	-90	-37	3.60		0.378
Occipital lobe	18			28	-94	-16	3.32		0.656
				23	-94	-18	3.26		0.713
Insight- patients > healthy controls
Nil significant
Healthy controls > Insight+ patients
Nil significant
Insight+ patients > healthy controls
Nil significant

BA: Brodmann area; L: Left; R: Right; MNI: Montreal Neurological Institute.