Systems psychopharmacology: A network approach to developing novel therapies

Figure 3 Topological, functional, and disease modules. Locally densely connected topological modules (grey circles) contrast with functional modules (circles connected by short, dashed lines), showing more (upper left), less or no overlap (center) with topological modules. The latter are preferentially associated with signal transduction pathways. Disease modules (nodes shown as dark squares, and connected by long, dashed lines) overlap with topological and functional modules, but may be less intensively connected and occupy more peripheral sites of networks.