Isotretinoin was not associated with depression or anxiety: A twelve-week study

Table 2 Frequency of depression and anxiety according to the Zung scales at baseline and during treatment

ITT				OT
Categorical level of depression [n (%)]1
	Basal	Week 6	Week 12	Basal	Week 6	Week 12
Mild	1 (2.8)	3 (8.3)	3 (8.3)	2 (8.3)	2 (8.3)	2 (8.3)
Moderate	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Severe	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Total	1 (2.8)	3 (8.3)	3 (8.3)	2 (8.3)	2 (8.3)	2 (8.3)
Categorical level of anxiety [n (%)]2
	Basal	Week 6	Week 12	Basal	Week 6	Week 12
Mild	1 (2.8)	2 (5.5)	1 (2.8)	1 (4.2)	0 (0.0)	0 (0.0)
Moderate	0 (0.0)	1 (2.8)	2 (5.5)	0 (0.0)	0 (0.0)	0 (0.0)
Severe	0 (0.0)	0 (0.0)	1 (2.8)	0 (0.0)	0 (0.0)	1 (4.2)
Total	1 (2.8)	3 (8.3)	4 (11.1)	1 (4.2)	0 (0.0)	1 (4.2)

Values represent number and percentage in parentheses of subjects with depression or anxiety.

¹Within-group comparisons: ITT group: χ² (2) = 1.2, P = 0.5; OT group: χ² (2) = 0.0, P = 1; between-group comparison: χ² (5) = 1.3, P = 0.9;

²Within-group comparisons: ITT group: χ² (2) = 4.6, P = 0.6; OT group: χ² (2) = 4.0, P = 0.4; between-group comparison: χ² (5) = 4.8, P = 0.4. OT: Other treatments; ITT: Isotretinoine.