Psychiatric aspects of brain tumors: A review

Table 1 Brain tumors and depressive symptoms[41]

Ref.	Psychiatric symptoms	Tumor location	Tumor type	Remarks
Zivković et al[42], 2014	Depression, impairment in memory, motivation, concentration, insomnia, increased appetite, headaches	Parietal lobe	Epidermoid tumor	Subsequent neurological symptoms led to CT scan and diagnosis of the brain tumor
Assefa et al[43], 2012	Depression, anxiety, insomnia, headache, nausea, vomiting, unilateral abducens palsy	Parasellar and retrosellar areas of the petrous apex, temporal lobe	Meningioma	Neurologic deficit with psychiatric symptoms
Ozdilek et al[44], 2011	Depression, anxiety, headache	Left temporal lobe	Glial tumor	Persistent headache led to neurologic consult and CT, and diagnosis
Cheema et al[45], 2010	Depression, anhedonia, low energy, insomnia, suicidal ideations	Left frontal and temporal lobe	Glioblastoma multiforme	Duration of psychiatric symptoms of 10 yr make the association of glioblastoma questionable and possibly unrelated
Bunevicius et al[46], 2008	Depression, Parkinsonian symptoms	Right fronto-temporal	Meningioma	Subsequent neurological symptoms led to CT scan and diagnosis of the brain tumor
Bunevicius et al[46], 2008	Depression, psychosis	Left temporal lobe	Intra-cerebral cyst	Refractory symptoms
Habermeyer et al[47], 2008	Depression, delirium	Right frontal lobe	Glioblastoma multiforme	Psychiatric and neurological symptoms at initial presentation
Oreskovic et al[48], 2007	Depression, attention deficit hyperactivity disorder	Suprasellar and pineal regions	Germ cell tumor	Good prognosis with chemotherapy and radiation
Moise et al[49], 2006	Depression, headache, memory loss	Right thalamus	Glioblastoma multiforme	Partial improvement of symptoms with surgical treatment and antidepressants
Madhusoodanan et al[50], 2004	Recent depressive symptoms, anger and agitation	Left parietal	High grade glial neoplasm with sporadic cells	Resolution of depressive symptoms after surgery, chemo- and radiation therapy
Kohler et al[32], 2001	Depressive symptoms refractory to antidepressants, following surgical resection of left frontal neurocytoma	Left lateral ventricle, left frontal encephalomalacia	Neurocytoma	Good response to ECT
Ghaziuddin et al[31], 1999	Depressed mood, mania, suicidal ideation, irritability, guilt, grandiosity, early insomnia, olfactory hallucinations	Brainstem (ponto-mesencephalic)	Astrocytoma	Improvement with ECT
Kaplan[51], 1997	Progressive depression and anxiety	Right frontal and parietal	Unknown
Kugaya et al[52], 1996	Depressed mood, agitation, depersonalization, ideas of reference, suicidal ideation	Ependymal	Cyst	Partial removal of cyst led to complete resolution of symptoms
Griffith[53], 1995	Depression	Olfactory area	Esthesioneuroblastoma
Filley et al[8], 1995	Severe depression, extensive weight loss	Left frontal	Squamous cell carcinoma
Chipkevitch et al[54], 1993	Atypical anorexia nervosa, depression	Hypothalamus	Teratoma
Fulton et al[55], 1992	Reduced communication, depression, seizures, neurologic signs	Right frontal lobe	Astrocytoma	Poor response to steroid treatment
Goodman et al[56], 1992	Late-onset depressive symptoms, left-sided Horner’s syndrome	Several bi-frontal masses	Unknown
Ko et al[57], 1989	Depressive symptoms, emotional lability, amnesia for recent events	Multiple metastatic left fronto-parietal lesions	Origin in right lung	No surgical intervention
Tanaghow et al[58], 1989	Depressed mood, social withdrawal, personal neglect, apathy	Anterior corpus callosum	Unknown
Upadhyaya et al[59], 1988	Depression and delusions	Third ventricle	Colloid cyst
Greenberg et al[29], 1988	Treatment-resistant depression with delusions	Left fronto-parietal	Meningioma	Good response of psychiatric symptoms to ECT
Goldstein et al[30], 1988	Depression	Right frontal	Meningioma	Good response to ECT
Summerfield[60], 1987	Depression, psychosomatic symptoms	Cerebellum	Hemangioblastoma
Ghadirian et al[61], 1986	Depression and anxiety followed by visual hallucinations	Right temporal lobe	Meningioma
Uribe[62], 1986	Depressive symptoms with rage episodes, forgetfulness, disturbance in short-term memory and abstract thinking, later-onset headaches, disorientation, gait unsteadiness, hemiparesis	Left temporo-parietal	Glioblastoma multiforme
Dietch[63], 1984	Agoraphobia with panic attacks and major depression; later-onset right-sided weakness	Left fronto-parietal	Glioblastoma multiforme	Good response to imipramine, resolution of symptoms after surgery
Maurice-Williams et al[64], 1984	Depression, focal seizures	Frontal	Meningioma	Improvement of symptoms after tumor was removed
Fisher et al[65], 1983	Depression	Limbic system	CNS lymphoma
Barbizet et al[66], 1982	Rage attacks, Bulimia, uninhibited and brutal sexual behavior, periods of depression with suicide attempts	Fronto-temporal	Astrocytoma
Lahmeyer[67], 1982	Depression and urinary incontinence	Bilateral frontal	Meningioma	Good response to amphetamines
Littman et al[68], 1981	Depression, speech difficulties	Left temporal	Unknown
Khuan et al[69], 1979	Depression, poor work performance	Right thalamus	Unknown
Burkle et al[70], 1978	Depression, hypersomnia, anhedonia, low energy, poor concentration, memory lapses	Third ventricle with obstruction of lateral ventricles	Colloid cyst
Carlson[71], 1977	Severe depression; prior history of seizures	Frontal	Meningioma	Complete resolution of symptoms after surgery
Carlson[71], 1977	Severe depression	Right frontal	Grade IV astrocytoma	Resolution of symptoms after surgery
Scherrer et al[72], 1974	Depression followed by euphoria, then seizures	Frontal	Unknown
Blustein et al[73], 1972	Depression	Right temporal	Grade I astrocytoma
Avery[74], 1971	Depression, apathy	Right cribriform plate	Meningioma	Post-op manic episode before resolution of symptoms
Avery[74], 1971	Depression, apathy	Right cribriform plate	Meningioma	Improvement after surgery

Adapted from Trends in Brain Cancer Research. New York: Nova Science Publishers Inc., 2006. ECT: Emission computed tomography; CT: Computed tomography.