Copyright
©The Author(s) 2015.
World J Psychiatr. Jun 22, 2015; 5(2): 170-181
Published online Jun 22, 2015. doi: 10.5498/wjp.v5.i2.170
Published online Jun 22, 2015. doi: 10.5498/wjp.v5.i2.170
Table 2 Randomised Controlled Trials investigating antidepressant effect of transcranial magnetic stimulation in older subjects (mean age of sample > 60)
| Trial | Age range | TMS parameters | Sample size | Methodology | Results |
| Manes et al[30] 2001 | 60.7 ± 9.8 | 20 Hz; 80%MT; left DLPFC; 800 pulses/session; 5 sessions; no. of pulses = 4000 | 20 (sham = 10) | Double blind RCT with handle as sham in subjects with one antidepressant failure aged 50-70, withdrawn from antidepressants for 5 d | No sham vs active differences; in each group 30% responded. Non-responders had reduced frontal volume. No drop-outs due to adverse effects |
| Mosimann et al[31] 2004 | 62 + 12 | 20 Hz; 100%MT; left DLPFC; 1600 pulses/session; 10 sessions; no. of pulses = 16000 | 24 (sham = 9) | Double blind RCT with tilted-sham in 40-90 years old subjects with TRD | No sham vs active differences |
| Jorge et al[32] 2008 (Trial 1) | 62.9 (7.2) | 10 Hz; 110%MT; MRI-based target localisation of left DLPFC; 1200 pulses/session; 10 sessions; no. of pulses = 12000 | 30 (sham = 15) | Double blind RCT with look-alike sham coil in subjects > 50 yr age with vascular depression and failed at least one antidepressant; all patients medication-free for at least 4 d before TMS | Age inversely correlated with response; frontal volume positively correlated with response. Active treatment: 33.3% responders; sham: 6.7% responders. No drop-outs due to adverse events |
| Jorge et al[32] 2008 (Trial 2) | 64.3 (9.4) | 10 Hz; 110%MT; MRI-based target localisation of left DLPFC; 1200 pulses/session; 15 sessions; no. of pulses = 18000 | 62 (sham = 29) | Double blind RCT with look-alike sham coil in subjects > 50 yr age with vascular depression and failed at least one antidepressant; all patients medication-free for at least 4 d before TMS | Active treatment: 39.4% responders; sham: 6.9% responders. Older subjects had better response for higher dose. No drop-outs due to adverse events |
- Citation: Sabesan P, Lankappa S, Khalifa N, Krishnan V, Gandhi R, Palaniyappan L. Transcranial magnetic stimulation for geriatric depression: Promises and pitfalls. World J Psychiatr 2015; 5(2): 170-181
- URL: https://www.wjgnet.com/2220-3206/full/v5/i2/170.htm
- DOI: https://dx.doi.org/10.5498/wjp.v5.i2.170