Review
Copyright ©The Author(s) 2015.
World J Psychiatr. Mar 22, 2015; 5(1): 15-34
Published online Mar 22, 2015. doi: 10.5498/wjp.v5.i1.15
Figure 2
Figure 2 Diagram illustrating connectivity between frontal lobe regions, including the dorsolateral prefrontal cortex (Brodmann area 9, BA9,) and orbitofrontal cortex (BA11) which regulate attention and executive function, and temporal lobe structures including the amygdala and hippocampus which regulate mood and memory. Frontal lobe connectivity with limbic structures is mediated in part by the uncinate fasciculus and superior longitudinal fasciculus which develop during gestation and undergo significant maturation during childhood and adolescence. Reduced frontal circuit connectivity is exhibited by DHA-deficient non-human primates, children and adolescents born preterm, and patients with psychiatric disorders including ADHD and bipolar disorder which are associated with DHA deficits. DHA: Docosahexaenoic acid; ADHD: Attention deficit/hyperactivity disorder.