Review
Copyright ©The Author(s) 2015.
World J Psychiatr. Mar 22, 2015; 5(1): 103-111
Published online Mar 22, 2015. doi: 10.5498/wjp.v5.i1.103
Table 1 Genes and polymorphisms associated with postpartum depression
ArticleRef.CountryInstrumentGenesPolymorphisms
CYP2D6 genotypes and depressive symptoms during late pregnancy and postpartumJosefsson et al[53]SwedenEPDSCYP2D6CYP2D6*1 (wild type), CYP2D6*3, CYP2D6*4
Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese womenSun et al[60]ChinaSADSTPH1T3840A, A12517C, A20004C, G347T, T27224C
Mood changes after delivery: role of the serotonin transporter geneSanjuan et al[58]SpainEPDS/DIGS5HTT5HTTLPR, STin2 VNTR
The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMTDoornbos et al[52]NetherlandEPDSMAOA, 5HTT, COMTMAOA , 5HTTLPR, COMT Val158Met
Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum womenLin et al[55]ChinaSADSTPH2T-703G, T-473A, A90G, C2755A, C10662T, G93329A
Genome-wide linkage and follow-up association study of postpartum mood symptomsMahon et al[64]United StatesDIGS417 microsatellite markers in linkage studies / 16.916 SNPs in the 1 and 9 chromosomes for GWAS.
Blood mononuclear cell gene expression signature of postpartum depressionSegman et al[59]IsraelEPDSPBMC gene expression3142 active transcripts set
A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohortBinder et al[49]United StatesSCID/HRSD-175HTT5HTTLPR
Association study of 44 candidate genes with depressive and anxiety symptoms in post-partum womenCostas et al[51]SpainEPDS/DIGS44 genes involved in pathways hipothetically related to the etiology of postpartum mood disorders: HPA axis, effects of stress in the prefrontal cortex, and regulation of sex hormones388 SNPs
An association study between the Val66Met polymorphism of the BDNF gene and postpartum depressionFigueira et al[47]BrazilEPDSBDNFBDNF Val66Met
Postpartum depression symptoms: a case-control study on monoaminergic functional polymorphisms and environmental stressorsComasco et al[50]SwedenEPDSCOMT, MAOA, 5HTTCOMT Val158Met, MAOA uVTNR, 5HTTLPR.
Role of mother’s genes and environment in postpartum depressionMitchell et al[57]United StatesCIDI-SF5HTT5HTTLPR , STin2 VNTR
Postpartum depressive symptoms and the BDNF Val66Met functional polymorphism: effect of season of deliveryComasco et al[50]SwedenEPDSBDNF, 5HTT, PER2BDNF Val66Met, PER2 SNP 10870 (G and A), 5HTTPLR (L and S)
Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotypeLewis et al[54]EnglandEPDSMTHFRC677T
The 5-HTTLPR polymorphism modulates the influence on environmental stressors on peripartum depression symptomsMehta et al[56]GermanyEPDS5HTT5HTTLPR
Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancyFasching et al[61]GermanyEPDSTPH2rs11178993, rs6582071, rs11178997, rs7955501, rs17110536, rs4760814, rs7300641, rs4760820, rs10879354, rs1487275, rs10879358, rs11615016, rs17110747, rs1872824
Postpartum depression symptoms associated with Val158Met COMT polymorphismAlvim-Soares et al[62]BrazilEPDSCOMTCOMT Val158Met
Interaction between oxytocin genotypes and early experience predicts quality of mothering and postpartum moodMileva-Seitz et al[63]CanadaCES-DOXT, OXTROXT: rs2740210, rs4813627/ OXTR: rs237885
Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partumEngineer et al[65]United KingdomEPDSGR, CRHR1GR: BclI, ER22/23EK/CRHR1: s1876828, rs242939, rs242941
Association study of the estrogen receptor gene ESR1 with postpartum depression - a pilot studyPinsonneault et al[66]CanadaMINI, SCID, EPDS and/or MADRSESR1, COMT, TPH2, DRD2, HTR2A, DAT, MAOA, 5HTTESR1: TA repeat, rs2077647, rs1801132, rs3798577, rs988328, rs1884051, rs3020327, rs9340958, rs3020434/HTR2A: rs6314, rs6311/DAT: rs27072, rs6347, In8VNTR/5HTTLPR/MAOA: rs1137070, pVNTR/TPH2: rs7305115 / DRD2: rs2283265 / COMT: rs4680