Serum NfL and GFAP levels and their association with anxiety-depression in Alzheimer’s disease patients: A clinical retrospective study

Table 2 Correlation between biomarker levels and Hospital Anxiety and Depression Scale scores

Biomarker	HADS-A (r)	P value	HADS-D (r)	P value	HADS-total (r)
NfL (pg/mL)	0.448	< 0.001	0.562	< 0.001	0.516
GFAP (pg/mL)	0.422	< 0.001	0.528	< 0.001	0.492
Age	0.186	0.002	0.198	0.001	0.194
MMSE score	-0.312	< 0.001	-0.346	< 0.001	-0.332
CDR score	0.298	< 0.001	0.324	< 0.001	0.314
Disease duration	0.224	< 0.001	0.256	< 0.001	0.242

HADS: Hospital Anxiety and Depression Scale; HADS-A: Hospital Anxiety and Depression Scale-Anxiety subscale; HADS-D: Hospital Anxiety and Depression Scale-Depression subscale; NfL: Neurofilament light chain; GFAP: Glial fibrillary acidic protein; MMSE: Mini-Mental State Examination; CDR: Clinical dementia rating; r: Spearman correlation coefficient.