Serum NfL and GFAP levels and their association with anxiety-depression in Alzheimer’s disease patients: A clinical retrospective study

doi:10.5498/wjp.121407

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 9

This Article

(2)

(0)

(4)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Psychiatry

ISSN

2220-3206

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Sep 19, 2026; 16(9): 121407
Published online Sep 19, 2026. doi: 10.5498/wjp.121407

Table 1 Baseline characteristics of study subjects, n (%)/mean ± SD

Characteristics	Total (n = 270)	AD-Control (n = 148)	AD-AnxDep (n = 122)
Age (years)	73.1 ± 8.3	72.3 ± 8.0	74.1 ± 8.7
Male gender	125 (46.3)	70 (47.3)	55 (45.1)
Education (years)	9.8 ± 3.6	10.2 ± 3.8	9.3 ± 3.4
Disease duration (years)	2.8 ± 1.4	2.6 ± 1.3	3.1 ± 1.5
MMSE score	18.5 ± 4.2	19.5 ± 4.1	17.3 ± 4.2
CDR score	1.2 ± 0.5	1.1 ± 0.4	1.4 ± 0.5
Hypertension	156 (57.8)	82 (55.4)	74 (60.7)
Diabetes mellitus	89 (33.0)	46 (31.1)	43 (35.2)
Hyperlipidemia	112 (41.5)	58 (39.2)	54 (44.3)
NfL (pg/mL)	26.7 ± 9.4	21.6 ± 6.4	32.8 ± 8.6
GFAP (pg/mL)	155.6 ± 47.2	127.8 ± 34.8	187.2 ± 43.2

AD-AnxDep: Alzheimer’s disease patients with coexisting anxiety-depression; AD-control: Alzheimer’s disease patients without coexisting anxiety-depression; MMSE: Mini-Mental State Examination; CDR: Clinical dementia rating; NfL: Neurofilament light chain; GFAP: Glial fibrillary acidic protein.

Full Size Table

Citation: Xu GW, Zhu XL, Yin CH. Serum NfL and GFAP levels and their association with anxiety-depression in Alzheimer’s disease patients: A clinical retrospective study. World J Psychiatry 2026; 16(9): 121407
URL: https://www.wjgnet.com/2220-3206/full/v16/i9/121407.htm
DOI: https://dx.doi.org/10.5498/wjp.121407

Xu GW, Zhu XL, Yin CH. Serum NfL and GFAP levels and their association with anxiety-depression in Alzheimer’s disease patients: A clinical retrospective study. World J Psychiatry 2026; 16(9): 121407 [DOI: 10.5498/wjp.121407]

All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.