Predictive factors for post-cerebral infarction depression: A retrospective study of 156 patients

Table 5 Independent predictors of post-stroke depression: Multivariate logistic regression

Variable	β	SE	Wald	OR (95%CI)	P value
Psychiatric history	1.348	0.298	20.45	3.85 (2.15-6.89)	< 0.001
Frontal lobe infarction	1.166	0.273	18.23	3.21 (1.88-5.48)	< 0.001
BDNF < 15.8 ng/mL	1.088	0.280	15.10	2.97 (1.72-5.13)	< 0.001
NIHSS ≥ 8	0.986	0.269	13.42	2.68 (1.58-4.54)	< 0.001
Female gender	0.896	0.244	13.48	2.45 (1.52-3.95)	0.001
Low social support	0.838	0.263	10.15	2.31 (1.38-3.87)	0.002
IL-6 > 6.5 pg/mL	0.779	0.285	7.48	2.18 (1.25-3.81)	0.006
Left hemisphere lesion	0.668	0.282	5.61	1.95 (1.12-3.39)	0.018
Non-significant variables
Homocysteine > 15 μmol/L	0.512	0.295	3.01	1.67 (0.94-2.97)	0.083
Morning cortisol > 360 nmol/L	0.598	0.312	3.67	1.82 (0.99-3.35)	0.055
WMH Fazekas ≥ 4	0.425	0.278	2.34	1.53 (0.89-2.63)	0.126
Diabetes mellitus	0.382	0.265	2.08	1.47 (0.87-2.47)	0.149
Previous stroke	0.356	0.312	1.30	1.43 (0.78-2.63)	0.254
Admission glucose > 7.0	0.298	0.258	1.33	1.35 (0.81-2.24)	0.248

Hosmer-Lemeshow test: χ² = 6.82, P = 0.556. BDNF: Brain-derived neurotrophic factor; NIHSS: National Institutes of Health Stroke Scale; IL: Interleukin; WMH: White matter hyperintensities; OR: Odds ratio; CI: Confidence interval.