Predictive factors for post-cerebral infarction depression: A retrospective study of 156 patients

doi:10.5498/wjp.120517

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World Journal of Psychiatry

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2220-3206

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Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Sep 19, 2026; 16(9): 120517
Published online Sep 19, 2026. doi: 10.5498/wjp.120517

Table 3 Neuroimaging findings, mean ± SD/n (%)

Imaging feature	PSD group (n = 68)	Non-PSD group (n = 88)	P value
Infarct volume (cm³)	9.2 ± 3.1	5.1 ± 2.0	< 0.001
Multiple infarcts	28 (41.2)	25 (28.4)	0.089
White matter hyperintensities
Fazekas periventricular	2.1 ± 0.6	1.2 ± 0.5	< 0.001
Fazekas deep WM	1.9 ± 0.5	1.0 ± 0.4	< 0.001
Fazekas total score	4.0 ± 1.0	2.2 ± 0.8	< 0.001
Brain atrophy
GCA frontal	1.8 ± 0.6	1.1 ± 0.5	< 0.001
GCA parietal	1.3 ± 0.5	1.0 ± 0.4	0.065
MTA score	1.6 ± 0.7	1.0 ± 0.5	0.003
Global atrophy (GCA total)	1.5 ± 0.5	1.1 ± 0.4	0.012
Microbleed count	2.8 ± 1.9	1.5 ± 1.2	0.009
Perfusion parameters
ADC (× 10^-3 mm²/second)	0.80 ± 0.11	0.90 ± 0.12	0.032
TTP (seconds)	122 ± 12	108 ± 9	0.018
CBF (mL/100 g/minutes)	32.5 ± 6.8	38.2 ± 7.5	0.028

WM: White matter; GCA: Global cortical atrophy; MTA: Medial temporal atrophy; ADC: Apparent diffusion coefficient; TTP: Time to peak; CBF: Cerebral blood flow; PSD: Post-stroke depression.

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Citation: Yang JY, Hu BH, Liu FZ, Gao YX. Predictive factors for post-cerebral infarction depression: A retrospective study of 156 patients. World J Psychiatry 2026; 16(9): 120517
URL: https://www.wjgnet.com/2220-3206/full/v16/i9/120517.htm
DOI: https://dx.doi.org/10.5498/wjp.120517

Yang JY, Hu BH, Liu FZ, Gao YX. Predictive factors for post-cerebral infarction depression: A retrospective study of 156 patients. World J Psychiatry 2026; 16(9): 120517 [DOI: 10.5498/wjp.120517]

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