Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance

doi:10.5498/wjp.119917

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Sep 19, 2026; 16(9): 119917
Published online Sep 19, 2026. doi: 10.5498/wjp.119917

Table 4 Comparison of blood glucose and blood lipid levels

	T2DM group (n = 40)	T2DM + anxiety group (n = 58)	T2DM + depression group (n = 52)	T2DM + anxiety-depression group (n = 47)	F	P value
HbA1c (%)	7.33 ± 1.78	7.48 ± 1.50	7.60 ± 1.51	8.39 ± 1.27^a^,^b^,^c	4.550	0.004
FPG (mmol/L)	9.86 ± 2.53	10.31 ± 2.73	10.51 ± 2.25	11.69 ± 3.22^a^,^b^,^c	3.576	0.015
2hPG (mmol/L)	15.57 ± 2.55	16.11 ± 3.12	16.10 ± 2.91	17.64 ± 1.67^a^,^b^,^c	5.154	0.002
TG (mmol/L)	2.04 ± 0.50	2.52 ± 0.68^a	2.35 ± 0.72^a	2.58 ± 0.80^a	5.354	0.002
TC (mmol/L)	5.36 ± 0.58	4.55 ± 0.60^a	4.55 ± 0.50^a	4.41 ± 0.44^a	27.10	< 0.0001
HDL-C (mmol/L)	1.93 ± 0.53	1.38 ± 0.31^a	1.39 ± 0.35^a	1.29 ± 0.23^a	27.45	< 0.0001
LDL-C (mmol/L)	2.03 ± 0.27	2.48 ± 0.32^a	2.43 ± 0.44^a	2.62 ± 0.62^a	14.94	< 0.0001
hs-CRP (mg/L)	2.41 ± 0.34	2.68 ± 0.33^a	2.71 ± 0.34^a	2.88 ± 0.39^a^,^b^,^c	13.68	< 0.0001

^aP < 0.05 vs type 2 diabetes mellitus group.

^bP < 0.05 vs type 2 diabetes mellitus + anxiety group.

^cP < 0.05 vs type 2 diabetes mellitus + depression group.

T2DM: Type 2 diabetes mellitus; HbA1c: Glycosylated hemoglobin; FPG: Fasting plasma glucose; 2hPG: 2-hour postprandial blood glucose; TG: Triglyceride; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; hs-CRP: High-sensitivity C-reactive protein.

Full Size Table

Citation: Wu CC, Sun WH, Yang QQ, Xue L, Zhao WD. Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance. World J Psychiatry 2026; 16(9): 119917
URL: https://www.wjgnet.com/2220-3206/full/v16/i9/119917.htm
DOI: https://dx.doi.org/10.5498/wjp.119917

Wu CC, Sun WH, Yang QQ, Xue L, Zhao WD. Anxiety-depression comorbidity prevalence in type 2 diabetes mellitus and correlation with insulin resistance. World J Psychiatry 2026; 16(9): 119917 [DOI: 10.5498/wjp.119917]

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