Anatomical specificity of post-stroke depression: Subcortical lesions, age-related patterns, and predictors of treatment response

Table 5 Detailed comparison of clinical characteristics and psychiatric symptoms by infarct location, mean ± SD/n (%)

Infarct location		Infarct volume (mL)	National Institutes of Health Stroke Scale score	Hamilton Anxiety Rating Scale score	Hamilton Depression Rating Scale score	Comorbidity rate (%)	Response rate (%)
Frontal lobe	34 (13.3)	18.6 ± 8.4	7.2 ± 2.6	23.1 ± 5.8	24.5 ± 6.1	73.5	76.5
Temporal lobe	28 (10.9)	15.2 ± 7.1	6.5 ± 2.3	21.4 ± 5.2	22.8 ± 5.4	67.9	78.6
Parietal lobe	20 (7.8)	12.8 ± 6.2	5.9 ± 2.1	20.8 ± 5.0	21.6 ± 5.2	65.0	80.0
Basal ganglia/internal capsule	76 (29.7)	8.5 ± 4.2	7.8 ± 2.7	22.8 ± 5.7	26.2 ± 6.4c	71.1	72.4
Thalamus	36 (14.1)	6.2 ± 3.1	6.3 ± 2.4	21.9 ± 5.4	25.1 ± 6.0b	69.4	75.0
Occipital lobe	18 (7.0)	10.4 ± 5.8	5.2 ± 1.9	20.2 ± 4.9	21.8 ± 5.3	61.1	83.3
Pons	26 (10.2)	3.8 ± 2.1	8.1 ± 2.8	22.3 ± 5.6	22.9 ± 5.9	69.2	76.9
Cerebellum	18 (7.0)	5.6 ± 2.8	6.8 ± 2.5	21.2 ± 5.3	21.5 ± 5.6	66.7	77.8
F/χ2/P value	-	28.45/< 0.001	6.82/< 0.001	1.28/0.264	10.52/< 0.001	3.25/0.862	3.82/0.801

^bP < 0.01.

^cP < 0.001 vs cerebral cortical lesions (frontal, temporal, parietal, occipital lobes combined).

Comorbidity rate: Percentage of patients with both anxiety and depression (Hamilton Anxiety Rating Scale ≥ 14 and Hamilton Depression Rating Scale ≥ 17). Response rate: Percentage of patients achieving favorable treatment response. Statistical analysis: One-way analysis of variance for continuous variables, χ² test for categorical variables.