Anatomical specificity of post-stroke depression: Subcortical lesions, age-related patterns, and predictors of treatment response

doi:10.5498/wjp.118381

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Sep 19, 2026; 16(9): 118381
Published online Sep 19, 2026. doi: 10.5498/wjp.118381

Table 3 Multivariate logistic regression analysis of treatment response

Variable	B	SE	Odds ratio (95%CI)	Wald	P value
Combined traditional Chinese medicine (yes = 1)	1.230	0.312	3.42 (1.86-6.29)	15.562	< 0.001
Baseline Hamilton Anxiety Rating Scale score	-0.085	0.030	0.92 (0.87-0.97)	8.028	0.005
Disease duration	-0.022	0.011	0.98 (0.96-0.99)	4.000	0.046
Hypertension (yes = 1)	-0.654	0.315	0.52 (0.28-0.96)	4.312	0.038

Model χ² = 42.86, P < 0.001; Hosmer-Lemeshow test χ² = 6.425, P = 0.598; Nagelkerke R² =0.235.

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Citation: Gu JX, Zhang MJ, Li FR, Wang X, Li SS. Anatomical specificity of post-stroke depression: Subcortical lesions, age-related patterns, and predictors of treatment response. World J Psychiatry 2026; 16(9): 118381
URL: https://www.wjgnet.com/2220-3206/full/v16/i9/118381.htm
DOI: https://dx.doi.org/10.5498/wjp.118381

Gu JX, Zhang MJ, Li FR, Wang X, Li SS. Anatomical specificity of post-stroke depression: Subcortical lesions, age-related patterns, and predictors of treatment response. World J Psychiatry 2026; 16(9): 118381 [DOI: 10.5498/wjp.118381]

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