Anatomical specificity of post-stroke depression: Subcortical lesions, age-related patterns, and predictors of treatment response

doi:10.5498/wjp.118381

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Sep 19, 2026; 16(9): 118381
Published online Sep 19, 2026. doi: 10.5498/wjp.118381

Table 2 Univariate logistic regression analysis of treatment response

Variable	B	SE	Odds ratio (95%CI)	Wald	P value
Gender (male = 1)	-0.186	0.285	0.83 (0.47-1.46)	0.426	0.514
Age	-0.032	0.015	0.97 (0.94-1.00)	4.556	0.033
Disease duration	-0.025	0.010	0.98 (0.96-1.00)	6.250	0.012
Combined traditional Chinese medicine (yes = 1)	1.386	0.298	4.00 (2.23-7.18)	21.645	< 0.001
Hypertension (yes = 1)	-0.586	0.296	0.56 (0.31-1.00)	3.918	0.048
Baseline Hamilton Anxiety Rating Scale score	-0.086	0.028	0.92 (0.87-0.97)	9.439	0.002
Baseline Hamilton Depression Rating Scale score	-0.065	0.025	0.94 (0.89-0.99)	6.760	0.009

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Citation: Gu JX, Zhang MJ, Li FR, Wang X, Li SS. Anatomical specificity of post-stroke depression: Subcortical lesions, age-related patterns, and predictors of treatment response. World J Psychiatry 2026; 16(9): 118381
URL: https://www.wjgnet.com/2220-3206/full/v16/i9/118381.htm
DOI: https://dx.doi.org/10.5498/wjp.118381

Gu JX, Zhang MJ, Li FR, Wang X, Li SS. Anatomical specificity of post-stroke depression: Subcortical lesions, age-related patterns, and predictors of treatment response. World J Psychiatry 2026; 16(9): 118381 [DOI: 10.5498/wjp.118381]

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