Application of medication therapy management-based “in-hospital assessment - home-based intervention” pharmaceutical care in patients with depression

Table 7 Comparison of incidence of adverse drug reactions between two groups of patients with depression

Adverse reaction type	Time point	Intervention group (n = 52)	Control group (n = 52)	χ2 value	P value
Nausea/vomiting	3 months	3 (5.77)	8 (15.38)	2.385	0.123
	6 months	6 (11.54)	12 (23.08)	3.385	0.066
	9 months	8 (15.38)	15 (28.85)	3.924	0.048
Dry mouth	3 months	7 (13.46)	14 (26.92)	3.038	0.081
	6 months	11 (21.15)	19 (36.54)	3.836	0.050
	9 months	13 (25.00)	22 (42.31)	4.217	0.040
Constipation	3 months	3 (5.77)	7 (13.46)	1.785	0.181
	6 months	6 (11.54)	12 (23.08)	3.385	0.066
	9 months	7 (13.46)	14 (26.92)	4.563	0.033
Sexual dysfunction	3 months	2 (3.85)	6 (11.54)	2.385	0.123
	6 months	6 (11.54)	14 (26.92)	4.217	0.040
	9 months	10 (19.23)	18 (34.62)	5.038	0.025
Sleep disturbance	3 months	6 (11.54)	12 (23.08)	3.385	0.066
	6 months	10 (19.23)	18 (34.62)	4.217	0.040
	9 months	12 (23.08)	20 (38.46)	4.872	0.027
Overall adverse reaction incidence	3 months	12 (23.08)	22 (42.31)	4.217	0.040
	6 months	20 (38.46)	34 (65.38)	7.836	0.005
	9 months	27 (51.92)	40 (76.92)	8.326	0.004

Data are presented as n (%).