Comprehensive psychological and neurological rehabilitation for post-stroke depression: A retrospective comparative study with biomarker exploration

Table 5 Multivariable logistic regression analysis of independent predictors of treatment response

Variable	β	SE	Wald χ2	OR (95%CI)	P value
Early psychological intervention initiation (≤ 2 weeks)	1.416	0.302	21.98	4.12 (2.28-7.44)	< 0.001
Baseline serum NPY ≥ 82.5 pg/mL	1.217	0.281	18.75	3.38 (1.95-5.86)	< 0.001
Mild-to-moderate depression (HAMD-17 < 17)	1.079	0.286	14.24	2.94 (1.68-5.14)	< 0.001
High family involvement (FSQ ≥ 28)	0.975	0.264	13.64	2.65 (1.58-4.44)	< 0.001
Intact cognition (MMSE ≥ 24)	0.884	0.261	11.45	2.42 (1.45-4.04)	0.001
Non-dominant hemisphere lesion	0.732	0.273	7.19	2.08 (1.22-3.55)	0.008
Baseline IL-1β < 8.2 pg/mL	0.621	0.269	5.33	1.86 (1.10-3.15)	0.021
Non-significant variables (P ≥ 0.10)
Homocysteine < 15 μmol/L	0.468	0.278	2.83	1.60 (0.93-2.75)	0.093
Baseline NSE < 15 μg/L	0.435	0.265	2.69	1.55 (0.92-2.60)	0.101
Infarct volume < 10 cm3	0.388	0.258	2.26	1.47 (0.89-2.44)	0.133
No diabetes mellitus	0.342	0.260	1.73	1.41 (0.85-2.34)	0.189
Good collateral circulation	0.318	0.272	1.37	1.37 (0.81-2.33)	0.242

Hosmer-Lemeshow goodness-of-fit: χ² = 6.45, P = 0.597. OR: Odds ratio; CI: Confidence interval; NPY: Neuropeptide Y; HAMD-17: Hamilton Depression Rating Scale-17; FSQ: Family support questionnaire; MMSE: Mini-Mental State Examination; IL: Interleukin; NSE: Neuron-specific enolase.