Comprehensive psychological and neurological rehabilitation for post-stroke depression: A retrospective comparative study with biomarker exploration

doi:10.5498/wjp.122383

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World Journal of Psychiatry

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2220-3206

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Retrospective Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 122383
Published online Aug 19, 2026. doi: 10.5498/wjp.122383

Table 2 Stroke-related clinical features and neuroimaging parameters, mean ± SD/n (%)

Parameter	CRG (n = 96)	CG (n = 82)	P value
Admission NIHSS	8.2 ± 3.2	8.6 ± 3.5	0.445
Frontal lobe involvement	30 (31.3)	24 (29.3)	0.774
Basal ganglia-internal capsule	28 (29.2)	24 (29.3)	0.988
Limbic structures	20 (20.8)	16 (19.5)	0.832
Prefrontal-striato-thalamic circuit	26 (27.1)	22 (26.8)	0.967
Dominant hemisphere	58 (60.4)	50 (61.0)	0.941
Infarct volume (cm³)	10.2 ± 4.5	10.8 ± 4.8	0.395
Multiple infarcts	38 (39.6)	32 (39.0)	0.939
Fazekas total score	2.8 ± 1.2	3.0 ± 1.3	0.292
Periventricular WMH (Fazekas)	1.5 ± 0.6	1.6 ± 0.7	0.328
Deep WMH (Fazekas)	1.3 ± 0.6	1.4 ± 0.6	0.292
GCA frontal score	1.4 ± 0.6	1.5 ± 0.6	0.295
MTA score	1.3 ± 0.6	1.4 ± 0.7	0.348
Microbleed count	1.8 ± 1.4	1.9 ± 1.5	0.678
TOAST classification
Large artery atherosclerosis	32 (33.3)	28 (34.1)	0.895
Cardioembolism	18 (18.8)	14 (17.1)
Small vessel occlusion	34 (35.4)	30 (36.6)
Cryptogenic/other	12 (12.5)	10 (12.2)
ASITN/SIR collateral grade
0-1 (poor)	28 (29.2)	24 (29.3)	0.812
2-3 (moderate)	42 (43.8)	36 (43.9)
4 (good)	26 (27.1)	22 (26.8)

CRG: Comprehensive rehabilitation group; CG: Control group; NIHSS: National Institutes of Health Stroke Scale; WMH: White matter hyperintensity; GCA: Global cortical atrophy scale; MTA: Medial temporal atrophy; TOAST: Trial of Org 10172 in Acute Stroke Treatment; ASITN/SIR: American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology.

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Citation: Yan SZ, Hu ZY, Zhou HY, Chai S. Comprehensive psychological and neurological rehabilitation for post-stroke depression: A retrospective comparative study with biomarker exploration. World J Psychiatry 2026; 16(8): 122383
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/122383.htm
DOI: https://dx.doi.org/10.5498/wjp.122383

Yan SZ, Hu ZY, Zhou HY, Chai S. Comprehensive psychological and neurological rehabilitation for post-stroke depression: A retrospective comparative study with biomarker exploration. World J Psychiatry 2026; 16(8): 122383 [DOI: 10.5498/wjp.122383]

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