Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients

doi:10.5498/wjp.122295

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 122295
Published online Aug 19, 2026. doi: 10.5498/wjp.122295

Table 4 Risk stratification based on number of elevated biomarkers

Number of elevated biomarkers	n	AD incidence (%)	OR (95%CI)	P value
0 (low risk)	24	12.5	Reference	-
1 (low-intermediate risk)	31	25.8	2.42 (0.68-8.62)	0.172
2 (intermediate-high risk)	32	50.0	6.84 (2.08-22.52)	0.002
3 (high risk)	38	78.9	26.32 (7.24-95.68)	< 0.001
P for trend	-	-	-	< 0.001

Elevated biomarkers defined as: IL-6 > 10 pg/mL, TNF-α > 20 pg/mL, p-tau181 > 18 pg/mL. AD: Anxiety-depression; OR: Odds ratio; CI: Confidence interval.

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Citation: Hu X, Tao J, Jiang YL, Liu K. Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients. World J Psychiatry 2026; 16(8): 122295
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/122295.htm
DOI: https://dx.doi.org/10.5498/wjp.122295

Hu X, Tao J, Jiang YL, Liu K. Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients. World J Psychiatry 2026; 16(8): 122295 [DOI: 10.5498/wjp.122295]

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