Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients

Table 3 Univariate analysis of risk factors for anxiety and depression

Risk factor	Odds ratio	95%CI	P value
Age ≥ 75 years	1.86	0.92-3.76	0.086
Female gender	1.72	0.88-3.36	0.112
MMSE ≤ 18	2.24	1.12-4.48	0.022
Elevated IL-6 (> 10 pg/mL)	3.24	1.58-6.65	0.001
Elevated TNF-α (> 20 pg/mL)	2.92	1.44-5.92	0.003
Elevated p-tau181 (> 18 pg/mL)	3.56	1.72-7.38	< 0.001

CI: Confidence interval; MMSE: Mini-Mental State Examination; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; p-tau181: Phosphorylated tau-181.