Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients

doi:10.5498/wjp.122295

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Aug 19, 2026; 16(8): 122295
Published online Aug 19, 2026. doi: 10.5498/wjp.122295

Table 2 Correlation between biomarker levels and Hospital Anxiety and Depression Scale scores

Biomarker	HADS-A (r)	P value	HADS-D (r)	P value	HADS-Total (r)
IL-6 (pg/mL)	0.418	< 0.001	0.524	< 0.001	0.486
TNF-α (pg/mL)	0.445	< 0.001	0.556	< 0.001	0.512
p-tau181 (pg/mL)	0.482	< 0.001	0.598	< 0.001	0.558

HADS-A: Hospital Anxiety and Depression Scale-Anxiety subscale; HADS-D: Hospital Anxiety and Depression Scale-Depression subscale; HADS: Hospital Anxiety and Depression Scale; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; p-tau181: Phosphorylated tau-181; r: Spearman correlation coefficient.

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Citation: Hu X, Tao J, Jiang YL, Liu K. Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients. World J Psychiatry 2026; 16(8): 122295
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/122295.htm
DOI: https://dx.doi.org/10.5498/wjp.122295

Hu X, Tao J, Jiang YL, Liu K. Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients. World J Psychiatry 2026; 16(8): 122295 [DOI: 10.5498/wjp.122295]

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