Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients

doi:10.5498/wjp.122295

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 122295
Published online Aug 19, 2026. doi: 10.5498/wjp.122295

Table 1 Baseline characteristics of study subjects, n (%)/mean ± SD

Characteristics	Total (n = 125)	Non-anxiety-depression group (n = 69)	AD group (n = 56)	P value
Age (years)	72.8 ± 8.6	71.9 ± 8.2	73.9 ± 9.0	0.198
Male gender	56 (44.8)	32 (46.4)	24 (42.9)	0.696
MMSE score	18.4 ± 4.2	19.4 ± 4.2	17.2 ± 4.0	0.004
IL-6 (pg/mL)	12.4 ± 4.8	9.6 ± 3.1	15.8 ± 4.2	< 0.001
TNF-α (pg/mL)	22.8 ± 7.6	18.2 ± 5.4	28.4 ± 6.8	< 0.001
p-tau181 (pg/mL)	20.1 ± 6.2	16.4 ± 4.2	24.6 ± 5.8	< 0.001

AD: Anxiety-depression; MMSE: Mini-Mental State Examination; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; p-tau181: Phosphorylated tau-181.

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Citation: Hu X, Tao J, Jiang YL, Liu K. Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients. World J Psychiatry 2026; 16(8): 122295
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/122295.htm
DOI: https://dx.doi.org/10.5498/wjp.122295

Hu X, Tao J, Jiang YL, Liu K. Predictive value of serum inflammatory factors combined with p-tau181 for anxiety and depression in Alzheimer’s disease patients. World J Psychiatry 2026; 16(8): 122295 [DOI: 10.5498/wjp.122295]

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