Assessment of nerve growth factor levels and clinical indicators for outcome prediction in first-episode schizophrenia

Table 3 Receiver operating characteristic curve of variable sensitivity vs specificity

Variable	AUC	95%CI	P value	Youden index	Sensitivity	Specificity	PPV	NPV
NGF0	0.830	0.728-0.906	< 0.001	0.647	89.66	75.00	91.2	71.4
NGF1	0.842	0.742-0.915	< 0.001	0.647	89.66	75.00	91.2	71.4
NGF1 - NGF0	0.800	0.694-0.882	< 0.001	0.557	70.69	85.00	93.2	50.0
Early improvement	0.674	0.559-0.776	0.021	0.348	44.83	90.00	92.9	36.0
Combined variables	0.925	0.843-0.972	< 0.001	0.716	96.55	75.00	92.8	88.2

AUC: Area under the curve; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; NGF₀: Baseline nerve growth factor; NGF₁: Nerve growth factor at 2 weeks after onset of antipsychotics treatment.