Effect of sodium valproate on aripiprazole pharmacokinetics and initial dosage optimization in bipolar disorder

doi:10.5498/wjp.v16.i8.120073

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Aug 19, 2026; 16(8): 120073
Published online Aug 19, 2026. doi: 10.5498/wjp.v16.i8.120073

Table 3 Parameter estimates of aripiprazole final model and bootstrap validation in bipolar disorder patients

Parameter	Estimate	SE	Bootstrap
Parameter	Estimate	SE	Median	95% confidence interval¹
CL/F (L/hour)	2.42	0.03	2.41	2.22-2.84
V/F (L)	425	0.16	439	174-581
Ka (hour^-1)	1.06 (fixed)
θ_VPA²	0.667	0.16	0.643	0.163-0.911
ω_V/F³	0.068	5.38	0.003	0.003-0.431
σ₁⁴	0.222	0.13	0.220	0.003-0.279
σ₂⁵	25.826	0.26	23.685	0.010-41.213

¹95% confidential interval is displayed as the 2.5^th, 97.5^th percentile of bootstrap estimates.

²θ_VPA is the coefficient of sodium valproate sustained-release tablet.

³ω_V/F, inter-individual variability of apparent volume of distribution.

⁴σ₁, residual variability, proportional error.

⁵σ₂, residual variability, additive error.

CL/F: Apparent oral clearance; V/F: Apparent volume of distribution; Ka: Absorption rate constant.

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Citation: He SM, Zhang CX, Jin YW, Jiang L, Zhang C, Jiang YG, Wang DD. Effect of sodium valproate on aripiprazole pharmacokinetics and initial dosage optimization in bipolar disorder. World J Psychiatry 2026; 16(8): 120073
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/120073.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i8.120073

He SM, Zhang CX, Jin YW, Jiang L, Zhang C, Jiang YG, Wang DD. Effect of sodium valproate on aripiprazole pharmacokinetics and initial dosage optimization in bipolar disorder. World J Psychiatry 2026; 16(8): 120073 [DOI: 10.5498/wjp.v16.i8.120073]

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