Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association

doi:10.5498/wjp.119686

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Aug 19, 2026; 16(8): 119686
Published online Aug 19, 2026. doi: 10.5498/wjp.119686

Table 4 Prevalence of psychological comorbidities in various “disorders of gut-brain interaction” subgroups with stratification according to overlap status, n (%)

DGBI groups	Anxiety prevalence				Depression prevalence
DGBI groups	All patients	Patients with a single DGBI	Patients with overlapping DGBIs	P value (single vs overlapping DGBIs)	All patients	Patients with a single DGBI	Patients with overlapping DGBIs	P value (single vs overlapping DGBIs)
All DGBIs	671/1044 (64.2)	329/623 (52.8)	342/421 (81.2)	0.0001	395/1044 (37.8)	179/623 (28.7)	216/421 (51.3)	0.0001
Esophageal Disorders (n = 348)	248/348 (71.2)	79/143 (55.2)	169/205 (82.4)	0.0001	138/348 (39.6)	35/143 (24.5)	103/205 (50.2)	0.0001
Gastroduodenal disorders (n = 521)	362/521 (69.5)	85/177 (32.8)	8277/344 (80.5)	0.0001	227/521 (43.6)	49/177 (27.7)	178/344 (51.7)	0.0001
Bowel disorders (n = 415)	273/415 (65.8)	122/221 (55.2)	151/194 (78.4)	0.0001	173/415 (41.7)	72/221 (32.6)	101/194 (52.6)	0.0001
Centrally mediated disorders of gastrointestinal pain (n = 48)	36/48 (75)	15/24 (62.5)	21/24 (87.5)	0.0933	23/48 (47.9)	8/24 (33.3)	15/24 (62.5)	0.0820
Gall bladder and sphincter of Oddi disorders (n = 14)	10/14 (71.42)	7/11 (63.63)	3/3 (100)	0.5055	5/14 (35.7)	4/11 (36.4)	1/3 (33.3)	1
Anorectal disorders (n = 65)	39/65 (60)	20/46 (43.47)	19/19 (100)	0.0001	22/56 (39.28)	10/46 (21.73)	12/19 (63.15)	0.0012
All patients (n = 1044)	671/1044 (64.2)	329/623 (52.8)	342/421 (81.2)	0.0001	395/104 (37.83)	179/623 (28.73)	216/421 (51.30)	0.0001

DGBI: Disorder of gut-brain interaction.

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Citation: Goyal MK, Goyal O, Wander P, Kaur J, Prashar G, Goyal P, Sood A. Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association. World J Psychiatry 2026; 16(8): 119686
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/119686.htm
DOI: https://dx.doi.org/10.5498/wjp.119686

Goyal MK, Goyal O, Wander P, Kaur J, Prashar G, Goyal P, Sood A. Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association. World J Psychiatry 2026; 16(8): 119686 [DOI: 10.5498/wjp.119686]

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