Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association

doi:10.5498/wjp.119686

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 119686
Published online Aug 19, 2026. doi: 10.5498/wjp.119686

Table 3 Comparison of clinical characteristics of “disorders of gut-brain interaction” patient groups with and without depression

Characteristics	Depression present (n = 395)	Depression absent (n = 649)	P value
Age (years)	42.5 ± 12.4	41.4 ± 12.7	0.1712
Female gender	241 (61.1%)	261 (40.2%)	0.0001
Body mass index (kg/m²)	23.3 ± 4.5	23.7 ± 4.2	0.1467
Duration of symptoms (years)	3.3 ± 4.6	2.3 ± 2.9	0.0001
Overlap DGBI present	216 (54.7%)	205 (31.6%)	0.0001
Anxiety present	361 (91.4%)	310 (47.7%)	0.0001
HRQoL Physical score	11.6 ± 3.1	15.3 ± 2.8	0.0001
HRQoL Mental score	10.8 ± 3.2	14.7 ± 2.6	0.0001

DGBI: Disorder of gut-brain interaction; HRQoL: Health-related quality of life.

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Citation: Goyal MK, Goyal O, Wander P, Kaur J, Prashar G, Goyal P, Sood A. Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association. World J Psychiatry 2026; 16(8): 119686
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/119686.htm
DOI: https://dx.doi.org/10.5498/wjp.119686

Goyal MK, Goyal O, Wander P, Kaur J, Prashar G, Goyal P, Sood A. Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association. World J Psychiatry 2026; 16(8): 119686 [DOI: 10.5498/wjp.119686]

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