Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association

doi:10.5498/wjp.119686

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Aug 19, 2026; 16(8): 119686
Published online Aug 19, 2026. doi: 10.5498/wjp.119686

Table 2 Comparison of clinical characteristics of “disorders of gut-brain interaction” patient groups with and without anxiety

Characteristics	Anxiety present (n = 671)	Anxiety absent (n = 373)	P value
Age (years)	42.2 ± 12.8	41.2 ± 12.2	0.219
Female gender	376 (56.1%)	126 (33.8%)	0.0001
Body mass index (kg/m²)	23.1 ± 4.8	23.9 ± 4.1	0.0067
Duration of symptoms (years)	2.9 ± 3.9	2.3 ± 2.7	0.0084
Overlap DGBI present	342 (50.9%)	79 (21.2%)	0.0001
Depression present	361 (53.8%)	34 (9.1%)	0.0001
HRQoL Physical score	11.9 ± 2.5	17.3 ± 1.6	0.0001
HRQoL Mental score	11.4 ± 2.8	16.4 ± 1.3	0.0001

DGBI: Disorder of gut-brain interaction; HRQoL: Health-related quality of life.

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Citation: Goyal MK, Goyal O, Wander P, Kaur J, Prashar G, Goyal P, Sood A. Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association. World J Psychiatry 2026; 16(8): 119686
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/119686.htm
DOI: https://dx.doi.org/10.5498/wjp.119686

Goyal MK, Goyal O, Wander P, Kaur J, Prashar G, Goyal P, Sood A. Anxiety and depression in Rome IV disorders of gut–brain interaction: Prevalence, clinical impact, and temporal association. World J Psychiatry 2026; 16(8): 119686 [DOI: 10.5498/wjp.119686]

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