Fluoxetine plus psychological intervention for chemotherapy-managed colon cancer patients: Impact on mood and influencing factors

Table 5 Mood improvement-associated determinants in chemotherapy-managed colon cancer patients (univariate screening), n (%)

Data	n	Ineffective group (n = 34)	Effective group (n = 111)	χ2 value	P value
Sex				2.154	0.142
Male	84	16 (47.06)	68 (61.26)
Female	61	18 (52.94)	43 (38.74)
Age (years)				2.605	0.107
< 60	73	13 (38.24)	60 (54.05)
≥ 60	72	21 (61.76)	51 (45.95)
Disease duration (months)				0.273	0.601
< 7	48	10 (29.41)	38 (34.23)
≥ 7	97	24 (70.59)	73 (65.77)
Tumor diameter (cm)				3.664	0.056
< 4	72	12 (35.29)	60 (54.05)
≥ 4	73	22 (64.71)	51 (45.95)
Lesion location				0.584	0.445
Left hemicolon	68	14 (41.18)	54 (48.65)
Right hemicolon	77	20 (58.82)	57 (51.35)
TNM staging				0.089	0.765
II	50	11 (32.35)	39 (35.14)
III	95	23 (67.65)	72 (64.86)
Chemotherapy regimen				0.584	0.445
mFOLFOX6	77	20 (58.82)	57 (51.35)
FOLFIRI	68	14 (41.18)	54 (48.65)
Educational level				0.591	0.442
Below senior high school	60	16 (47.06)	44 (39.64)
Senior high school or above	85	18 (52.94)	67 (60.36)
5-HT (ng/mL)				6.555	0.011
< 12	62	21 (61.76)	41 (36.94)
≥ 12	83	13 (38.24)	70 (63.06)
NE (pg/mL)				1.078	0.299
< 330	71	14 (41.18)	57 (51.35)
≥ 330	74	20 (58.82)	54 (48.65)
Treatment modality				28.337	< 0.001
Psychological intervention + fluoxetine	79	5 (14.71)	74 (66.67)
Psychological intervention	66	29 (85.29)	37 (33.33)

5-HT: 5-hydroxytryptamine; NE: Norepinephrine.