Beyond analgesia: A comprehensive opinion review on the dual-action strategy of celecoxib and duloxetine in knee osteoarthritis

doi:10.5498/wjp.116224

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Opinion Review

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Aug 19, 2026; 16(8): 116224
Published online Aug 19, 2026. doi: 10.5498/wjp.116224

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Figure 1 Sites of action (efficacy) of celecoxib and duloxetine. Celecoxib inhibits the cyclooxygenase-2 enzyme, reducing the production of prostaglandin E2 at the site of inflammation. Duloxetine increases serotonin and norepinephrine in the synaptic cleft, reinforcing the descending inhibitory pathway. COX-2: Cyclooxygenase-2.

Citation: Nagamine T. Beyond analgesia: A comprehensive opinion review on the dual-action strategy of celecoxib and duloxetine in knee osteoarthritis. World J Psychiatry 2026; 16(8): 116224
URL: https://www.wjgnet.com/2220-3206/full/v16/i8/116224.htm
DOI: https://dx.doi.org/10.5498/wjp.116224

Nagamine T. Beyond analgesia: A comprehensive opinion review on the dual-action strategy of celecoxib and duloxetine in knee osteoarthritis. World J Psychiatry 2026; 16(8): 116224 [DOI: 10.5498/wjp.116224]

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