Incidence, risk factors, and correlation with organ involvement of psychological disorders in patients with Sjögren’s syndrome

Figure 2 Comparison of autoimmune and inflammatory markers between psychological disorder and non-psychological disorder groups in Sjögren’s syndrome patients. A: Anti-SSA/Ro52 antibody positivity rate and complement component 3 (C3) level; B: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level. Patients with psychological disorders (PD) exhibited significantly more active autoimmune and inflammatory profiles, characterized by higher anti-SSA/Ro52 antibody positivity rates (82.1% vs 69.2%), lower complement C3 levels (85 ± 23 mg/L vs 94 ± 21 mg/L), and elevated inflammatory markers including ESR (42.3 ± 18.7 mm/hour vs 35.6 ± 16.2 mm/hour) and CRP (8.9 ± 12.4 mg/L vs 5.7 ± 8.3 mg/L). These laboratory findings suggest that PDs in Sjögren’s syndrome patients are associated with heightened systemic inflammation and more pronounced autoimmune activity, indicating a potential bidirectional relationship between immune dysfunction and mental health status. ^aP < 0.05. ESR: Erythrocyte sedimentation rate; CRP: C-reactive protein; C3: Complement component 3.