Divergent lymphocyte associations with depression severity and case status in first-episode, drug-naive adolescents: A multicenter study

Table 4 Immune marker differences across adolescence stages in depressed individuals

Variables	Early adolescence (n = 226)		Middle adolescence (n = 1492)		Late adolescence (n = 397)
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Neutrophils (× 109/L)	1.07 (0.92-1.24)	0.36	0.99(0.94-1.05)	0.86	1.04 (0.94-1.14)	0.45
Lymphocytes (× 109/L)	1.08 (0.80-1.46)	0.59	1.13 (1.01-1.27)	0.03	1.09 (0.89-1.32)	0.38
Monocytes (× 109/L)	1.74 (0.27-11.34)	0.56	0.78 (0.38-1.61)	0.50	1.08 (0.34-3.40)	0.89
LNR	0.90 (0.43-1.88)	0.78	1.25 (0.89-1.78)	0.19	1.20 (0.72-2.00)	0.47
NMR	1.04 (0.94-1.16)	0.41	1.01 (0.98-1.04)	0.51	1.04 (0.98-1.10)	0.24
LMR	1.04 (0.87-1.24)	0.62	1.09 (1.02-1.17)	0.01	1.07 (0.95-1.22)	0.26

Early adolescence (10-13 years), middle adolescence (14-17 years), and late adolescence (18-19 years). Model was adjusted for sex. LNR: Lymphocyte-to-neutrophil ratio; NMR: Neutrophil-to-monocyte ratio; LMR: Lymphocyte-to-monocyte ratio; OR: Odds ratio; CI: Confidence interval.