Divergent lymphocyte associations with depression severity and case status in first-episode, drug-naive adolescents: A multicenter study

Table 3 Relationship between immunological markers and depression in adolescents with major depressive disorder

Variables	Model 1				Model 2
	B	SE	OR (95%CI)	P value	B	SE	OR (95%CI)	P value
Neutrophils (× 109/L)	-0.4	0.2	0.64 (0.46-0.89)	0.008	-0.5	0.2	0.62 (0.44-0.87)	0.006
Lymphocytes (× 109/L)	-1.0	0.3	0.36 (0.19-0.69)	0.002	-1.3	0.4	0.27 (0.13-0.57)	< 0.001
Monocytes (× 109/L)	-0.9	1.9	0.41 (0.01-17.31)	0.642	-0.5	2.0	0.61 (0.01-29.12)	0.800
LNR	0.1	0.7	1.09 (0.29-4.03)	0.897	-0.1	0.7	0.93 (0.24-3.59)	0.921
NMR	-0.2	0.1	0.83 (0.71-0.98)	0.022	-0.2	0.1	0.82 (0.70-0.96)	0.015
LMR	-0.2	0.1	0.79 (0.63-0.98)	0.034	-0.3	0.1	0.72 (0.56-0.92)	0.009

Model 1 was unadjusted, and model 2 was adjusted for age and sex. LNR: Lymphocyte-to-neutrophil ratio; NMR: Neutrophil-to-monocyte ratio; LMR: Lymphocyte-to-monocyte ratio; OR: Odds ratio; CI: Confidence interval.