Divergent lymphocyte associations with depression severity and case status in first-episode, drug-naive adolescents: A multicenter study

doi:10.5498/wjp.119439

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jul 19, 2026; 16(7): 119439
Published online Jul 19, 2026. doi: 10.5498/wjp.119439

Table 1 Social demographic characteristics and immune markers across subgroups with different degrees of depression severity, n (%)/mean ± SD/median (interquartile rage)

Variables	Severity of depression			Total	H/χ²	P value
Variables	Mild	Moderate	Severe	Total	H/χ²	P value
Total	279 (13.19)	588 (27.80)	1248 (59.01)	2115 (100)
Age	16.22 ± 1.74	16.05 ± 1.72	15.75 ± 1.78	15.90 ± 1.77	25.95	< 0.001
Sex					112.06	< 0.001
Male	169 (21.86)	248 (32.08)	356 (46.06)	773 (36.55)
Female	110 (8.20)	340 (25.33)	892 (66.47)	1342 (63.45)
Area					2.43	0.297
Guangxi municipality	7 (10.14)	16 (23.19)	46 (66.67)	69 (3.26)
Jiangxi province	268 (13.74)	549 (28.14)	1134 (58.12)	1951 (92.25)
Shanghai province	4 (4.21)	23 (24.21)	68 (71.58)	95 (4.49)
WBC (× 10⁹/L)	6.58 (5.76-7.96)	7.03 (5.98-8.22)	6.98 (6.03-8.18)	6.95 (5.98-8.17)	9.31	0.009
Neutrophils (× 10⁹/L)	4.23 (3.40-5.28)	4.42 (3.46-5.89)	4.42 (3.46-5.75)	4.38 (3.46-5.76)	4.99	0.082
Lymphocytes (× 10⁹/L)	2.08 (1.61-2.70)	2.25 (1.68-2.80)	2.26 (1.71-2.88)	2.23 (1.68-2.84)	8.85	0.011
Monocytes (× 10⁹/L)	0.58 (0.51-0.68)	0.59 (0.52-0.68)	0.58 (0.51-0.67)	0.58 (0.51-0.68)	1.15	0.563
LNR	0.49 (0.35-0.70)	0.51 (0.35-0.70)	0.52 (0.36-0.72)	0.51 (0.36-0.71)	1.51	0.469
NMR	7.16 (5.76-9.08)	7.66 (5.94-9.51)	7.54 (5.96-9.46)	7.52 (5.94-9.44)	5.99	0.049
LMR	3.61 (2.66-4.40)	3.76 (2.92-4.83)	3.87 (3.00-4.90)	3.78 (2.92-4.83)	11.31	0.003

WBC: White blood cell; LNR: Lymphocyte-to-neutrophil ratio; NMR: Neutrophil-to-monocyte ratio; LMR: Lymphocyte-to-monocyte ratio.

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Citation: Fan XW, Hou JZ, Wang YZ, Gao ML, Shen Y, Jian D, Zhou Q, Yang J, Zhao H, Zhang LJ. Divergent lymphocyte associations with depression severity and case status in first-episode, drug-naive adolescents: A multicenter study. World J Psychiatry 2026; 16(7): 119439
URL: https://www.wjgnet.com/2220-3206/full/v16/i7/119439.htm
DOI: https://dx.doi.org/10.5498/wjp.119439

Fan XW, Hou JZ, Wang YZ, Gao ML, Shen Y, Jian D, Zhou Q, Yang J, Zhao H, Zhang LJ. Divergent lymphocyte associations with depression severity and case status in first-episode, drug-naive adolescents: A multicenter study. World J Psychiatry 2026; 16(7): 119439 [DOI: 10.5498/wjp.119439]

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