Serum adiponectin and cognitive function in Alzheimer’s disease with comorbid depression

doi:10.5498/wjp.118148

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World Journal of Psychiatry

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2220-3206

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Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jul 19, 2026; 16(7): 118148
Published online Jul 19, 2026. doi: 10.5498/wjp.118148

Table 3 Comparison of adiponectin levels and cognitive function scores among observation group patients with different disease severities, mean ± SD

	n	Serum APN (μg/mL)	MoCA scores	MMSE scores
Mild group	22	8.54 ± 1.23	20.12 ± 2.35	21.25 ± 4.62
Moderate group	24	6.39 ± 1.12^a	14.89 ± 2.13^a	16.31 ± 2.74^a
Severe group	14	4.19 ± 0.85^a^,^b	7.85 ± 1.54^a^,^b	8.78 ± 1.82^a^,^b
F		67.386	136.272	57.099
P value		< 0.001	< 0.001	< 0.001

^aP < 0.05 vs mild group.

^bP < 0.05 vs moderate group.

This table compares serum adiponectin levels and cognitive function scores (Montreal Cognitive Assessment and Mini-Mental State Examination) among patients in the observation group with different disease severities (mild, moderate, severe). One-way ANOVA was used for statistical analysis, followed by post hoc comparisons using LSD test. APN: Adiponectin; MoCA: Montreal Cognitive Assessment; MMSE: Mini-Mental State Examination.

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Citation: Song C, Zhan W, Tang JY, Liu ZH, Huang YP. Serum adiponectin and cognitive function in Alzheimer’s disease with comorbid depression. World J Psychiatry 2026; 16(7): 118148
URL: https://www.wjgnet.com/2220-3206/full/v16/i7/118148.htm
DOI: https://dx.doi.org/10.5498/wjp.118148

Song C, Zhan W, Tang JY, Liu ZH, Huang YP. Serum adiponectin and cognitive function in Alzheimer’s disease with comorbid depression. World J Psychiatry 2026; 16(7): 118148 [DOI: 10.5498/wjp.118148]

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