Effects of paroxetine on aripiprazole and individualized administration in depressed patients based on model-informed precision dosing

doi:10.5498/wjp.117458

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jul 19, 2026; 16(7): 117458
Published online Jul 19, 2026. doi: 10.5498/wjp.117458

Table 4 Initial dosage recommendation of aripiprazole in depressed patients

Without paroxetine hydrochloride tablet			With paroxetine hydrochloride tablet
Body weight (kg)	Dosage (mg/kg/day)	Probability to achieve the target concentrations (%)	Body weight (kg)	Dosage (mg/kg/day)	Probability to achieve the target concentrations (%)
40-80	0.5	99.4-99.8	40-120	0.3	99.7-100
80-120	0.4	99.3-99.5	-	-	-

Full Size Table

Citation: Jin YW, Zhang Y, Wang J, Jiang L, He SM, Zhang C, Wang DD. Effects of paroxetine on aripiprazole and individualized administration in depressed patients based on model-informed precision dosing. World J Psychiatry 2026; 16(7): 117458
URL: https://www.wjgnet.com/2220-3206/full/v16/i7/117458.htm
DOI: https://dx.doi.org/10.5498/wjp.117458

Jin YW, Zhang Y, Wang J, Jiang L, He SM, Zhang C, Wang DD. Effects of paroxetine on aripiprazole and individualized administration in depressed patients based on model-informed precision dosing. World J Psychiatry 2026; 16(7): 117458 [DOI: 10.5498/wjp.117458]

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