Effects of paroxetine on aripiprazole and individualized administration in depressed patients based on model-informed precision dosing

doi:10.5498/wjp.117458

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jul 19, 2026; 16(7): 117458
Published online Jul 19, 2026. doi: 10.5498/wjp.117458

Table 3 Parameter estimates of aripiprazole final model and bootstrap validation in depressed patients

Parameter	Estimate	SE (%)	Bootstrap
Parameter	Estimate	SE (%)	Median	95%CI
CL/F (L/hour)	3.12	7.6	3.14	2.70-3.70
V/F (L)	287	5.5	284	66-327
Ka (hour^-1)	1.06 (fixed)	-	-	-
θ_PAR	-0.533	16.9	-0.534	-0.696 to -0.189
ω_CL/F	0.489	18.6	0.479	0.299-0.699
σ₁	42.426	18.2	39.749	20.847-55.946

95% confidential interval was displayed as the 2.5^th, 97.5^th percentile of bootstrap estimates. CL/F: Apparent oral clearance; V/F: Volume of distribution; Ka: Absorption rate constant; θ_PAR: The coefficient of paroxetine hydrochloride tablet; ω_CL/F: Inter-individual variability of apparent oral clearance; σ₁: Residual variability, additive error; CI: Confidence interval.

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Citation: Jin YW, Zhang Y, Wang J, Jiang L, He SM, Zhang C, Wang DD. Effects of paroxetine on aripiprazole and individualized administration in depressed patients based on model-informed precision dosing. World J Psychiatry 2026; 16(7): 117458
URL: https://www.wjgnet.com/2220-3206/full/v16/i7/117458.htm
DOI: https://dx.doi.org/10.5498/wjp.117458

Jin YW, Zhang Y, Wang J, Jiang L, He SM, Zhang C, Wang DD. Effects of paroxetine on aripiprazole and individualized administration in depressed patients based on model-informed precision dosing. World J Psychiatry 2026; 16(7): 117458 [DOI: 10.5498/wjp.117458]

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