Goal-directed fluid therapy and cognitive outcomes in elderly surgical patients with anxiety and depression

Table 5 Relationship between regional cerebral oxygen saturation decline magnitude and postoperative cognitive dysfunction across subgroups

Subgroup	Adjusted odds ratio (95%CI)	P value	Interaction P value
Age stratification			0.156
< 70 years (n = 118)	1.38 (1.08-1.76)	0.009
≥ 70 years (n = 102)	1.52 (1.20-1.93)	< 0.001
Sex stratification			0.524
Male (n = 118)	1.41 (1.10-1.80)	0.006
Female (n = 102)	1.46 (1.14-1.87)	0.003
Anxiety-depression stratification			0.042
Non-anxiety-depression (n = 128)	1.35 (1.05-1.73)	0.022
Anxiety-depression (n = 92)	1.58 (1.25-2.00)	< 0.001
Fluid management strategy stratification			0.187
Goal-directed fluid therapy group (n = 110)	1.31 (1.02-1.68)	0.032
Conventional fluid therapy group (n = 110)	1.48 (1.19-1.84)	0.001
ASA classification stratification			0.428
ASA I and II (n = 169)	1.40 (1.13-1.74)	0.002
ASA III (n = 51)	1.52 (1.10-2.10)	0.012

ASA: American Society of Anesthesiologists.