Goal-directed fluid therapy and cognitive outcomes in elderly surgical patients with anxiety and depression

Table 4 Multivariate logistic regression analysis: Risk factors for postoperative cognitive dysfunction on postoperative day 1

Variable	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	Adjusted OR (95%CI)	P value
Age (per 5-year increase)	1.32 (1.08-1.62)	0.007	1.28 (1.04-1.58)	0.021
Male sex	0.87 (0.51-1.48)	0.609	-	-
American Society of Anesthesiologists class ≥ III	1.68 (0.88-3.21)	0.116	1.45 (0.73-2.88)	0.289
Surgical duration (per 1 hour increase)	1.42 (1.06-1.91)	0.019	1.35 (0.99-1.84)	0.056
Preoperative anxiety-depression	2.89 (1.67-5.01)	< 0.001	2.68 (1.52-4.73)	0.001
Fluid therapy modality (conventional fluid therapy vs goal-directed fluid therapy)	2.35 (1.36-4.06)	0.002	2.12 (1.20-3.75)	0.010
Regional cerebral oxygen saturation decline magnitude (per 5% increase)	1.52 (1.28-1.81)	< 0.001	1.43 (1.18-1.74)	< 0.001
Intraoperative hypotension duration (per 10 minutes increase)	1.38 (1.12-1.70)	0.003	1.26 (1.01-1.57)	0.042

OR: Odds ratio.