Perinatal anxiety and depressive symptoms in women with preeclampsia: A cohort study of placental dysfunction and neuroendocrine correlates

doi:10.5498/wjp.117183

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jul 19, 2026; 16(7): 117183
Published online Jul 19, 2026. doi: 10.5498/wjp.117183

Table 5 Salivary cortisol measures at enrollment, mean ± SD

Measure	Preeclampsia (n = 105)	Control (n = 105)	P value
Morning cortisol (nmol/L)	16.8 ± 4.2	14.1 ± 3.4	< 0.001
Cortisol awakening response (nmol/L)	3.2 ± 2.4	5.1 ± 2.8	< 0.001
Evening cortisol (nmol/L)	5.8 ± 2.1	4.2 ± 1.6	< 0.001
Diurnal slope (nmol/L/hour)	-0.68 ± 0.32	-0.82 ± 0.28	0.002
Area under the curve with respect to ground (nmol/L/hour)	198.4 ± 52.6	176.2 ± 41.8	0.001

Cortisol awakening response calculated as 30-minute post-awakening minus the awakening value. Area under the curve with respect to ground representing the total daily cortisol output.

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Citation: Ma J, Jiang YY. Perinatal anxiety and depressive symptoms in women with preeclampsia: A cohort study of placental dysfunction and neuroendocrine correlates. World J Psychiatry 2026; 16(7): 117183
URL: https://www.wjgnet.com/2220-3206/full/v16/i7/117183.htm
DOI: https://dx.doi.org/10.5498/wjp.117183

Ma J, Jiang YY. Perinatal anxiety and depressive symptoms in women with preeclampsia: A cohort study of placental dysfunction and neuroendocrine correlates. World J Psychiatry 2026; 16(7): 117183 [DOI: 10.5498/wjp.117183]

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